Research on production of a preparation with inhibitory effects on harmful algae Microcystis aeruginosa from Chrysanthemum indicum flowers

13/05/2025

Water quality has been and continues to be affected by various socio-economic development activities. The increase in nutrient levels, combined with favorable natural conditions, has led to the proliferation of algae, including harmful algae, in several water bodies in Vietnam. The growth of toxic cyanobacteria, notably Microcystis aeruginosa, has caused a decline in water quality, negatively impacting aquatic animals, ecosystems, and human health.

Within the framework of the Vietnam Academy of Science and Technology-level technological development project titled “Research on the production of a preparation with inhibitory effects on harmful algae Microcystis aeruginosa from Chrysanthemum indicum flowers”, code UDPTCN 04./22-24, chaired by Assoc. Prof. Dr. Le Thi Phuong Quynh and hosted by the Institute of Natural Products Chemistry, researchers have successfully developed a preparation named HCV from Chrysanthemum indicum flowers. This preparation has proven effective in inhibiting the growth of the toxic algae M. aeruginosa. Furan and flavonoid compounds identified in the yellow Chrysanthemum indicum flowers were determined to be the active ingredients responsible for inhibiting the growth of the cyanobacteria Microcystis aeruginosa. The project has established a technological process for extracting the preparation at a scale of 2 kg of dried flower material per batch, yielding the HCV product containing ≥60% phenolic compounds with high specificity in killing harmful algae.

The results demonstrate that the HCV preparation derived from Chrysanthemum indicum effectively inhibits harmful algae and contributes to solving water pollution problems. The findings provide a scientific foundation for future research on natural compounds for environmentally friendly treatment of harmful algae in aquatic systems.

IIn addition, the project has led to the publication of one article in an international SCIE-indexed journal, the granting of one exclusive patent, and the training of one Ph.D. candidate.