Essential oils Polyalthia Suberosa leaf and twig and their cytotoxic and antimicrobial activities

Essential oils from the leaf and twig of Polyalthia suberosa (Roxb.) Thwaites were analyzed using GC/MS/FID. A total of sixty-three constituents were namely identified accounting for 96.03 and 94.12% in the hydrodistilled oils of the leaf and twig, respectively. Monoterpenes, monoterpenoids, sesquiterpenes, and sesquiterpenoids were characteristic derivatives of P. suberosa essential oils. Sesquiterpenes bicyclogermacrene (26.26%) and (E)- caryophyllene (7.79 %), and monoterpene β-pinene (12.71%) were the major constituents of the leaf oil. Sesquiterpenes (E)-caryophyllene (17.17%) and α-humulene (9.55 %), sesquiterpenoid caryophyllene oxide (9.41 %), and monoterpenes camphene (8.16%) and tricyclene (6.35%) were to be main components in the twig oil. The leaf oil indicated cytotoxic activity against three cancer cell lines HepG2, MCF7 and A549 with the IC50values of 60.96–69.93 μg/mL, while the twig oil inhibited MCF7 with the IC50 value of 66.70 μg/mL. Additionally, the twig oil successfully suppressed the growth of the negative Gram bacterium Pseudomonas aeruginosa, fungus Aspergillus niger, and yeast Candida albicans with the same MIC value of 50 μg/mL, whereas the leaf oil had the same result on the negative Gram bacterium Escherichia coli.

The research work is a research collaboration of: Institute of Chemistry, Mien Trung Institute for Scientific Research-VNMN,  Institute of Natural Products Chemistry and Graduate University of Science and Technology.

Polyalthia suberosa (Roxb.) Thwaites (. (Photographs by L.T. Anh)

Source: Ninh The S, Anh LT, Thuy DTT, Luyen ND, Tuyen TT (2021). Essential Oils of Polyalthia suberosa Leaf and Twig and Their cytotoxic and Anti-microbial Activities. Chemistry & Biodiversity 18:1-7, ISSN: 1612-1872. Link: https://doi.org/10.1002/cbdv.20210002

News: Le Tuan Anh, Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, VAST
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