Essential oils of the leaf and stem of Polyalthia Viridis Craib and their biologial activities

Plant of the genus Polyalthia are considered to have potential for essential oils. Thirty-nine constituents (95.3%) were identified in the leaf oils and 42 constituents (90.9%) in the stem oils. Sesquiterpene hydrocarbons and oxygenated sesquiterpenes were the main constituents of both oils, in which 2 sesquiterpene hydrocarbons, germacrene D (45.1%-47.4%) and bicyclogermacrene (8.2%-17.1%), were the 2 major compounds. The stem oils inhibited the growth of 3 cancer cell lines, HepG2, MCF7, and A549, with half inhibitory concentration (IC50) values of 56.7 to 68.4 μg/mL.

The stem oils also successfully suppressed the growth of the filamentous fungus Aspergillus niger and the yeast Candida albicans with minimum inhibitory concentration values of 50 μg/mL. P. viridis oils suppressed NO production in lipopolysaccharide-stimulated BV2 microglial cells, with IC50 values of 57.6 to 76.7 μg/mL.

The work is the result of the project: "Screening the anti-inflammatory and anti-cancer effects of some Vietnamese medicinal plants and studying the phytochemistry of selected species", code: QTRU02.04/20- 21, under the cooperation of: Institute of Chemistry, Mien Trung Institute for Scientific Research-VNMN, Institute of Natural Products Chemistry University of Education, Hue University and Faculty of Chemical Technology, Hanoi University of Industry.

Fig. Polyalthia viridis Craib (Photographs by L.T. Anh)

Source: Ninh T. Son, Tuan A. Le, Dinh T. T. Thuy, Dinh L. Nguyen, Tran T. Tuyen, Minh D. Hoang Thi and Manh H. Nguyen (2021). Essential Oils of the Leaf and Stem of Polyalthia viridis Craib and Their Biological Activities. Natural Product Communications 16(9):1-6, ISSN 1934578X. Link:

News: Vietnam National Museum of Nature, VAST
Link to Vietnamese version

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