- Isolation and structural elucidation of secondary metabolites from several mangrove-derived fungal strains isolated from Xuan Thuy National Park.
- Evaluation of the cytotoxic and anti-inflammatory activities of the isolated compounds.

- 20 fungal strains were isolated from Excoecaria agallocha, Rhizophora stylosa, and Sonneratia caseolaris collected from Xuan Thuy National Park. Their total extracts of biomass-cultures were prepared.
- Anti-inflammatory activity (through inhibiting NO overproduction) and cytotoxicity (against two cancer cell lines HepG2 and MCF7) of 20 fungal strains were evaluated: strains XT37 and XT47 both showed inhibitory activity against NO overproduction and cytotoxicity toward both cell lines, while strain XT49 exhibited strong cytotoxicity on both tested cell lines. Many other fungal strains showed moderate to weak NO inhibitory activity or cytotoxicity.
- Three selected fungal strains XT37, XT47, and XT49 were taxonomically identified as Aspergillus sp. DVXT-221, Trichoderma sp. GXT-22.1 and Aspergillus sp. BCXT-22.1, respectively.
- 30 pure compounds were isolated from three fungal strains Aspergillus sp. DVXT-221, Aspergillus sp. GXT-22.1 và Trichoderma sp. BCXT-22.1. Their structures, including six new compounds, fumigaclavines K–M (XT37.1–XT37.3), 5′-(4-methoxyphenyl)-1′,3′-oxazole (XT47.1), polyporusterone H (XT49.1), and stellatinol A (XT49.4), along with one new natural compound, (E)-6,10-dimethyl-5-undecene-2,9,10-triol (XT47.2) were elucidated.
- Anti-inflammatory activity of compounds was evaluated through inhibiting overproduction of nitric oxide (NO):  compounds XT37.1 and XT37.9 exhibited the strongest effects (IC50 = 5.3 ± 0.2 and 8.7 ± 0.4 M); 16 compounds XT37.1XT37.4, XT37.8XT37.10, XT47.1XT47.5, XT47.8, XT47.10, XT49.4, and XT49.8 displayed weaker effects. Molecular docking simulation revealed that compounds XT37.1, XT37.9, XT47.1, XT49.4, and XT49.8 showed high binding affinity to the active site of the iNOS, with binding energies ranging from 12.71 to 6.34 kcal/mol.
- Cytotoxicity of compounds against three carcinoma cell lines HepG2, MCF7 and SK-Mel-2 were examined: compounds XT37.1 and XT37.3 displayed cytotoxicity against both HepG2 and MCF7 cell lines (IC50 = 61.1 ± 3.1  87.65 ± 3.49 M), compound XT49.1 was cytotoxic on all three tested cell lines  (IC50 = 75.41 ± 5.76  87.65 ± 3.49 M) but its cytotoxicity on the normal cell line HEK-293A remained undertermined (IC50 > 100 M). Many compounds from the strain XT49 showed moderate to weak cytotoxicity against both MCF7 and SK-Mel-2 cell lines.

- Isolation and structural elucidation of six new compounds, fumigaclavine K, fumigaclavine L, fumigaclavine M, 5-(4-methoxyphenyl)-1,3-oxazole, polyporusterone H and stellatinol A, and one new natural product, (E)-6,10-dimethyl-5-undecene-2,9,10-triol.
- Cytotoxicity of 16 compounds (XT37.3, XT37.6, XT37.9, XT47.1XT47.8, XT49.2, XT49.3, XT49.7, XT49.8, and XT49.10) was evaluated for the first time.
- NO inhibitory activity of 18 compounds (XT37.3, XT37.6, XT37.8XT37.10, XT47.1 XT47.8, XT47.10, XT49.5, XT49.7, XT49.8, and XT49.10) was examined for the first time.

- Scientific papers in referred journals (list): 03 SCIE papers.
+ Dang Viet Anh, Tran Hong Quang*, Ninh Thi Ngoc, Tran Thi Hong Hanh,
Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Nguyen Ngoc Tung, Nguyen Hoai Nam, Chau Van Minh. Fumigaclavines K-M, undescribed ergot alkaloids from the mangrove-derived fungus Aspergillus sp. DVXT-221 with cytotoxic and NO inhibitory activities. Tetrahedron, 2025; 171: 134414.
+ Dang Viet Anh, Do Hoang Anh, Le Thi Vien, Pham Thi Mai Huong, Nguyen Xuan Cuong, Nguyen Thi Thanh Ngan, Nguyen Ngoc Tung, Tran Hong Quang*. An Oxazole Alkaloid, Terpenoids, and Cyclodipeptides with Cytotoxic and NO Inhibitory Effects from a Mangrove-Derived Fungus Trichoderma sp. GXT-22.1. Chemistry & Biodiversity, 2024. 22(5): e202402986.
+ Dang Viet Anh, Le Thi Vien, Pham Thi Cham, Nguyen Hoang Nam, Nguyen Quoc Vuong, Nguyen Thi Thanh Ngan, Do Thi Thao, Dong-Sung Lee, Tran Hong Quang*. Ecdysteroids, Phenolics, and Alkaloids from a Mangrove-Derived Fungus Aspergillus sp. BCXT-22.1 with Cytotoxic and NO Inhibitory Activities. Chemistry & Biodiversity, 2025; 22(11): e01213
- Technological products (describe in details: technical characteristics, place):
+ A report on the isolation, biomass-culturing, and extraction of 20 fungal strains.
+ 20 fungal strains isolated from mangrove plant samples.
+ A report on the taxonomic identification of three selected fungal strains.
+ A report on large-scale fermentation and extraction of three selected fungal strains.
+ A report on the isolation and structural identification of 30 compounds from three fungal strains.
+ 30 compounds isolated from three fungal strains.
+ A report on the evaluation of anti-inflammatory and cytotoxic activities of 20 fungal strains and isolated compounds.
+ A list of bioactive fungal strains and compounds.
- Training result: supported training of 01 PhD student.

- Continue further studies on the anti-inflammatory activity of compounds XT37.1, XT37.9, XT47.1, XT49.4, and XT49.8 and the anti-cancer activity of compound XT49.1 to explore their underlying mechanisms of action.
- Continue studies on chemical composition of other bioactive fungal strains and antimicrobial activity of fungal metabolites and isolated compounds.