Vietnam Academy of Science and Technology

Project's information

Project's title	Study on isolation of bioactive compounds from marine-derived fungi and echinoderm collected from the 8th expedition aboard the R/V “Akademik Oparin” in Vietnam
Project’s code	QTRU02.05/23-24
Research hosting institution	Institute of Marine Biochemistry (IMBC)
Coordinating unit, co-chair	Pacific Institute of Bioorganic Chemistry
Project leader’s name	Tran Hong Quang and Pavel Dmitrenok
Project duration	01/01/2023 - 31/12/2024
Project’s budget	1,083 million VND
Classify	Excellent
Goal and objectives of the project	- Isolation, structural identification and evaluation of antibacterial and cytotoxic activities of natural compounds from marine-derived fungi and an echinoderm collected during the expedition. - Strengthening research cooperation with the Pacific Institute of Organic Biochemistry and training of the investigators in the direction of research of the project.
Main results	Research: - Participating in the expedition and contributing in collection of marine samples and sediments. - Isolation, fermentation, and creation of extracts of 40 fungal strains from the collected marine samples. - Taxonomic identification of 2 fungal strains. - Isolation and structural elucidation of 32 compounds from two fungal strains and one starfish. - Evaluation of antimicrobial effect of the extracts of 8 fungal strains, one starfish, and 25 compounds. - Evaluation of cytotoxicity of the extracts of 8 fungal strains, one starfish, and 14 compounds. Education and tranining: - Training 01 BSc and 01 MSc. Cooperation: - Visiting and exchanging ideas with the partner at the Pacific Institute of Organic Biochemistry, Russia.
Novelty and actuality and scientific meaningfulness of the results	- Isolation and structural elucidation of 2 new compounds and 2 new natural compounds. - Many compounds were found for the first time in Vietnam. - Antibacterial and antifungal activities of some compounds were evaluated for the first time. - Cytotoxicity of some compounds were examined for the first time..
Products of the project	- Publications: + 1st SCIE article: N.T. Ngoc, T.H. Quang, T.T.H. Hanh, N.X. Cuong, V.T. Quyen, N.T.T. Ngan, D.V. Ha, N.H. Nam, C.V. Minh, Cytotoxic and antimicrobial metabolites from the marine-derived fungus Aspergillus sp. OPR23-FS01, Phytochemistry Letters 61 (2024) 29-34. + 2nd SCIE article: L.T. Vien, T.T.H. Hanh, T.H. Quang, N.D. Ngai, D.V. Ha, N.X. Cuong, Culcinoside E, a new sulfated steroidal biglycoside from the starfish Culcita novaeguineae, Journal of Asian Natural Products Research 10.1080/10286020.2024.2434564 (2024) 1-7. + VAST1/Scopus/ESCI article: D.H. Anh, N.T. Tu, T.T.H. Hanh, N.X. Cuong, L.T. Vien, N.T.T. Ngan, D.V. Ha, T.H. Quang, Terpenes and polyketides from the marine-derived fungus Penicillium sp. OPR23-FS02 with cytotoxic and antimicrobial effects, Vietnam Journal of Chemistry 62 (2024) 638-646. - Patents: - Products (description...): + Product 1: Results of isolation, fermentation, and extraction of fungal strains and extraction of an echinoderm. Place of storage: Institute of Marine Biochemistry. + Product 2: Fungal strains isolated from marine samples. Place of storage: Institute of Marine Biochemistry. + Product 3: Results of taxonomic identification of 02 marine fungal strains. Place of storage: Institute of Marine Biochemistry. + Product 4: Results of chemical investigation of 02 marine fungal strains and 01 echinoderm. Place of storage: Institute of Marine Biochemistry. + Product 5: 32 pure compounds. Place of storage: Institute of Marine Biochemistry. + Product 6: Results of evaluation of antibacterial and cytotoxic activities of the fungal strains, an echinoderm, and isolated compounds. Place of storage: Institute of Marine Biochemistry. + Product 7: 19 bioactive compounds. Place of storage: Institute of Marine Biochemistry. - Other products: + Publication: 02 SCIE and 01 VAST1/Scopus/ESCI articles. + Training: 01 BSc and 01 MSc.
Recommendations	Further research is needed on chemical composition and biological activities of other potential fungal strains.
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