- Determine chemical constituents of Carallia brachiata (Rhizophoracea) and evaluate the anti-inflamatory activity of isolated compounds;
-  Prepare functional food from brand, leaves of  C. Brachiata, and its evaluated anti-inflamatory and anti-tumor activities.   

-    Theoretical results:
+ From the branches and leaves of C. Brachiata, fourteen compounds were isolated, including two new compounds being two catechin derivatives carabrachiatanins A (1) and B (2) along with twelve known compounds consisting of seven proanthocyanidins (3-9) and five flavonoids (10-14). 
+ The anti-inflammatory activity of the isolated compounds was evaluated through the inhibition of NO production of compounds 1-9. Results showed that  proanthocyanidin compounds (3-9) and phenylpropanoid-substituted catechin compounds (1-2) played an important role in inhibiting NO production in LPS-activated RAW264.7 cells. These compounds significantly inhibited NO production with IC50 values ranging from 13.72 ∼ 34.28 µM. Especially, two compounds 7 and 8 effectly inhibited with their IC50 values of 16.31 ± 0.61 µM and 16.53 ± 0.83 µM, respectively, compared to that of dexamethasone with IC50 value of 14.94 ± 1.11 µM.
+ A rational and feasible process of building functional food CbF at a scale of 55g/batch from branches and leaves of C. brachiata was developed. 
+ 110 g of  functional food CbF was successfully prepared. 
    + The anti-inflammatory activity of the product was evaluated through the inhibition of NO production in LPS-activated RAW264.7 cells. Moreover, its ability to reduce tumor size was assessed in mice bearing Lewis lung carcinoma (LLC) cells. Experimental results showed that in mice treated with the sample at doses of 100-200 mg/kg/day, there was no significant reduction in tumor volume compared to the negative control mice.
+ The basic standard of  functional food CbF was stablished with parameters including state, solubility, pH, sulfate ash, water content, qualitative, quantitative, heavy metal content, and microbiological testing.
-    Applied results: Carallia brachiata is a traditional medicinal plant used for treating inflammatory and tumor-related diseases.

- For the first time, the chemical constituents of Carallia brachiata in Viet Nam have been studied, 14 compounds were isolated, including two new compounds being two catechin derivatives carabrachiatanins A (1) and B (2) along with twelve known compounds. For the first time, the compounds 1-12 and 14 have been isolated from Carallia genus as well as C. brachiata. 
Furthermore, the anti-inflammatory activity of the isolated compounds (1-9) has been evaluated through their effective inhibition of NO production in LPS-activated RAW264.7 cells. Two compounds 7 and 8 effectly inhibited with their IC50 values of 16.31 ± 0.61 µM and 16.53 ± 0.83 µM, respectively, compared to that of dexamethasone with IC50 value of 14.94 ± 1.11 µM.
- The procedure for preparation of functional food CbF from brand and leaves of C. brachiata was developed, evaluating both its anti-inflammatory and anti-tumor activities, and establishing CbF Quality Control Standards.

- Scientific papers in referred journals (list):
+ 01 SCI-E: Van T. T. T, Nam N. H., Hue N. T., Thanh L. N., Trang D. T., Tai B. H., Tuan N. L., Ai N. T. V., Cuong P. V., Vuong N. Q., and Kiem P. V., (2023). Carabrachiatanins A and B: Two New Phenylpropanoid-Substituted Catechins of Carallia brachiata Merr.. Natural Product Communications, 18(12), 1–6. DOI: 10.1177/1934578X231219074.
+ 01 domestic specialized journal : Van T. T. T, Nam N. H., Hieu T. V., Nam V. V.,Thanh L. N., Quang T. H., Cuong P. V., Vuong N. Q., Isolation of flavonoids from leaves of Carallia brachiata Merr.. Journal of Analytical Sciences (2024), 30(2), 57-63.  
- Patents (list):
- Technological products (describe in details: technical characteristics, place): 
+ The specimen (VAST04.2/22-23) was kept at Institute of Marine Biochemistry (IMBC-VAST) 
+ The fourteen compounds (1-14) were kept at the Department of Medicinal Chemistry Technology (IMBC-VAST).

Carallia brachiata has been needed to study deeply on anti-inflamatory activity and lymphoma activity.