- Collected and authenticated the plant samples as Magnolia coriacea

- Nine compounds were isolated and elucidated from the leaves of Magnolia coriacea, including tritriacontan-1-ol (MCLE1), (+)-Spathulenol (MCLE2), 7-hydroxy dehydroglaucine (MCLE3), mangochinine acetate (MCLM4), rutin (MCLM5), quercitrin (MCLM6), oxytroflavoside G (MCLM7), rhamnocitrin 3-rutinoside (MCLM8) and curcucomoside D (MCLM9). 

- Seven compounds were isolated and elucidated from the twig of Magnolia coriacea, including phyten-1-yl-caprylate (MCR1), caryophyllenol-II (MCR2), pontevedrine (MCR3), O-methylatheroline (MCR4), (+)-glaucine N-oxide (MCR5), (+)-(S)-glaucine (MCR6), magnoflorine (MCR7) and N-methyl glaucine acetate (MCR8).

- The extracts of n-hexane, EtOAc and MeOH were tested for their cytotoxic activity against KB, LU, MCF7 and HepG2 cancer cell lines. The results showed that the EtOAc extract inhibited significantly on four tested cancer cell lines with the IC50 values of 8.9; 13.6; 2.3 and 13.46 g/ml, respectively. In particular, it seemed the most potent on Lu cancer cell line (IC50 = 2.3 g/ml), followed by KB cancer cell growth inhibitory activity (IC50 = 8.9 µ g/ml).

- Five compounds, MCR3, MCR4, MCR5, MCR6 and MCR8, were also evaluated for cytotoxic activity on KB, LU, MCF7 and HepG2 cancer cell lines. Among the tested compounds, only MCR4 showed weak cytotoxic activity on HepG2 cancer cell, with the IC50 values of 20.0 g/ml, whereas the other compounds were inactive.

- Studied acute toxicity on experimental rats of the product CPMCR. The results showed that at the dose level of 10000 mg/kg body weight did not cause a death of the orally administrated rats.

- A procedure for preparation of the product CPMCR, at scale of 2.0 kg of dried plant per patch, had successfully developed.

- Fundamental standards of the product CPMCR were created.

- Published an article in Vietnam Journal of Chemistry (2022); and an accepted article in Natural Product Communications (2023).