Project's information

Project's title Research on synthesis of biocompatible SPION/HAp superparamagnetic hybrid material system for application in drug delivery for bladder cancer treatment
Project’s code CT0000.09/21-23
Research hosting institution University of Science and Technology of Hanoi
Project leader’s name Prof.Dr. Dinh Thi Mai Thanh
Project duration 01/06/2021 - 31/12/2023
Project’s budget 1,000 million VND
Classify Grade B
Goal and objectives of the project

General objective: Synthesize a biocompatible hybrid material system based on superparamagnetic SPION and HAp for use in delivering the 5-fluorouracil drug against bladder cancer;
Specific goals: Synthesize SPION/HAp; SPION/HAp/5-fluorouracil; SPION/HAp/Cu and SPION/HAp/Cu/5-fluorouracil hybrid material systems meet the potential of 5-fluorouracil drug delivery in bladder cancer treatment.

Main results
- Scientific results: SPION/HAp material has been synthesized using 1-step and 2-step procedures, and SPION/HAp/5-fluorouracil, SPION/HAp/Cu, and SPION/HAp/Cu/5-fluorouracil composites have been synthesized; the ability to kill bladder cancer cells of synthesized materials were studied.
- Applied results: the results of the project can be applied to treat bladder cancer. High applicability because the precursors used to synthesize materials are all low-cost chemicals, the synthesis process is simple, not complicated, and does not require expensive equipment.
Novelty and actuality and scientific meaningfulness of the results SPION/HAp/5-fluorouracil, SPION/HAp/Cu, and SPION/HAp/Cu/5-fluorouracil materials were synthesized and have the ability to kill bladder cancer cells.
Products of the project

- Scientific papers in referred journals (list):
1. Dinh Thi Mai Thanh, Nguyen Thu Phuong, Do Thi Hai, Ha Ngan Giang, Nguyen Thi Thom, Pham Thi Nam, Nguyen Trung Dung, Michael Giersig, Magdalena Osial, Influence of experimental conditions during synthesis on the physicochemical properties of the SPION/Hydroxyapatite nanocomposite for magnetic hyperthermia applications, Magnetochemistry, 2022, 8, 90, https://doi.org/10.3390/magnetochemistry8080090.
2. Magdalena Osial, Giang Ngan Ha, Van Hong Vu, Phuong Thu Nguyen, Dorota Nieciecka, Paulina Pietrzyk, Olga Urbanek, Sunday Joseph Olusegun, Sławomir Wilczewski, Michael Giersig, Hai Thi Do, Thanh Thi Mai Dinh, One-pot synthesis of magnetic hydroxyapatite for 5-fluorouracil delivery and magnetic hyperthermia, Journal of Nanoparticle Research, 2024, 26:7.
3. Thu Phuong Nguyen, Slawomir Wilczewski, Jakub Lewandowski, Agnieszka Majkowska-Pilip, Kinga Zelechowska- Matysiak, Dorota Nieciecka, Waldemar Studzinski, Sunday Joseph Olusegun, Marcin Syczewski, Michael Giersig, Thi Mai Thanh Dinh, Pawel Krysinski, Magdalena Osial, 5-fluorouracil and curcuminoids extract from Curcuma longa L. loaded into nanohydroxyapatite as a drug delivery carrier for SCOV-3 and HepG2 cancer cells treatment, Ceramics International 49(15), 25775-25787.
- Patents (list):
- Technological products (describe in details: technical characteristics, place):
01 procedure to synthesize SPION/HAp hybrid materials
01 procedure to modify SPION/HAp hybrid material with copper
5 g modified composite product
Place of storage: University of Science and Technology of Hanoi
- Other products (if applicable):
Training: 02 students

Images of project
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