Project's information
| Project's title | Compounds with antiprotozoal activity from animal venoms and plants of Vietnam and Rusian |
| Project’s code | QTRU01.15/21-22 |
| Research hosting institution | Institute of Applied Materials Science (IAMS) |
| Coordinating unit, co-chair | Fund for Russian Basic Research |
| Project leader’s name | Prof. Le Tien Dung and Prof. Utkin Yuri Nicolaevic |
| Project duration | 01/05/2021 - 31/05/2023 |
| Project’s budget | 200 million VND |
| Classify | Excellent |
| Goal and objectives of the project | Study on the effects of animal and plant venoms in Vietnam and in Russia on protozoa. Isolation and structure determination of some compounds toxic to protozoa. |
| Main results | a) In terms of research results have been obtained:
- Collected venoms of 10 types of snakes and 1 type of scorpion distributed in Vietnam and Russia. The antiprotozoal activity of these venoms was investigated. The results showed that there are 4 species of cobra family (Elapidae) and 3 species of viper family (Viperidae) with antiprotozoal activity.
- Collected 15 types of plants distributed in Vietnam and Russia. The collection of these plants was carried out and their antiprotozoal activity was investigated. The results showed that there are 9 new plants with antiprotozoal activity.
- It has been determined that the venom of the krait snake (Bungarus multicinctus) has relatively high activity against protozoa. From this venom, together with the Russian side, we have isolated compounds with activity against protozoa. This compound is structurally determined and it is β-bungarotoxin (β-Bgt).
- Five compounds have been isolated from plant Scoparia dulcis and their structures have been determined. Investigation of the antiprotozoal activity of 3 compounds from them, it showed that one compound has moderate activity against protozoa, which is Ferruginoside C.
- Worked with Russia to process data, write and publish 2 articles in Russian magazines and 1 article in international journals.
b) In terms of training: Contribute to the training of a PhD in Chemistry
c) In terms of cooperation development: Completed the task of international cooperation in the period of 2021-2023. The obtained research results have contributed to the development of scientific cooperation with the Russian Fund for Basic Research. |
| Novelty and actuality and scientific meaningfulness of the results | For the first time, the venoms and plants with antiprotozoal activity were identified in Vietnam and Russia. For the first time, a compound with antiprotozoal activity has been isolated and determined from the venom of the snake Bungarus multicinctus, it is β-bungarotoxin (β-Bgt). For the first time, a compound with antiprotozoal activity was isolated and determined from the plant Scoparia dulcis, which is Ferruginoside C. |
| Products of the project | - Publications: |
| Recommendations | Continue to cooperate with the Russian Academy of Sciences in researching compounds with anti-protozoa activity from animal and plant venoms of Vietnam and Russia. This is a new field of Vietnam and Russia, animal venoms and medicinal plants are abundant in Vietnam but not so much in Russia. These herbs are applied in folk medicine, but they have not been studied to prepare drugs to treat diseases caused by protozoa. Therefore, cooperation in the field of research on compounds with anti-protozoal activity in the medicinal resources of Vietnam and Russia will yield many useful results in the medicine of both Vietnam and Russia. |
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