Research on synthesizing modified derivatives of cyclodextrin (CD) (containing amine functional group (NH2) or containing thiol functional group (-SH)), synthesizing and determining the characteristic structure of hybrid materials from the complex metal nanoparticles (AuNPs), and modified derivatives of cyclodextrin (CD) as novel drug carriers.

- Three cyclodextrin derivatives containing free amine groups have been synthesized from CD:

+ Mono-6-amino-deoxy-6-β-cyclodextrin (CD-NH2)

+ Mono-6-(1,3-trimethylene diamine)-6-deoxy-β-cyclodextrin (TMACD)

+ Mono-6-(1,6-hexamethylene diamine)-6-deoxy-β-cyclodextrin (HMACD)

- Three synthetic nanocomposite systems based on AuNPs and β-cyclodextrin derivatives (CD, HPCD, and TMACD) have determined the physicochemical properties of the materials by analytical tools: FT-IR, SEM, TEM, HR-TEM, SAED, zeta potential, particle size and thermal properties (TGA-DTA).

- Based on AuNPs and β-cyclodextrin derivatives (CD, HPCD, and TMACD), 5-FU was successfully loaded onto nanocomposite systems and determined the physicochemical properties of the materials as well as compared with the drug-free system. The results show that the AuNPs/TMACD system has the best drug-carrying efficiency.

- The drug delivery nanosystem has the ability to release drugs and protect drugs well in the blood physiological environment (pH 7.4). The drug release mechanism is due to the expansion of the cyclodextrin molecule and the Fickian diffusion mechanism contributes to the control factor for drug release.

- All CD-x and AuNPs/CD-x derivative materials were non-toxic to normal cells. The two nanocomposites 5-FU@AuNPs/CD and 5-FU@AuNPs/TMACD showed good inhibitory ability on the breast cancer cell line MCF-7 and safety for normal cells.

The topic has prepared new materials based on gold nano and β-cyclodextrin derivatives and successfully loaded 5-FU on these materials. The nanocomposites of 5‑FU@AuNPs/TMACD and 5-FU@AuNPs/CD have potential applications in cancer treatment.

- New materials based on gold nanoparticles and β-cyclodextrin derivatives have been prepared.

- Successfully carried 5-FU drug, formed 5-FU@AuNPs/CD and 5‑FU@AuNPs/TMACD nanocomposite systems.

- The 5-FU drug was released from the nanocomposites of 5-FU@AuNPs/CD and 5‑FU@AuNPs/TMACD and showed that the nanocomposite system protected the drug well in the blood physiological environment (pH 7.4).

- Tested for biological activity. All CD-x and AuNPs/CD-x materials are non-toxic to normal cells; nanocomposites of 5-FU@AuNPs/CD and 5-FU@AuNPs/TMACD were well inhibited on MCF-7 and safety in normal cells, so they have potential applications in cancer treatment.

- Scientific papers in referred journals (list):

1. Cao-Hien Nguyen, Kien-Sam Banh, Chi-Hien Dang*, Cong-Hao Nguyen, Thanh-Danh Nguyen* (2022) β-cyclodextrin/alginate nanoparticles encapsulated 5-fluorouracil as an effective and safe anticancer drug delivery system, Arabian Journal of Chemistry, 15 (6), 103814. (SCIE, Q.1, IF (2021) = 6.212).

2. Cao-Hien Nguyen†, Kien-Sam Banh†, Van-Dung Le, Minh-Ty Nguyen, Chi-Hien Dang*, Tran Vinh Thien*, Van-Dat Doan, DongQuy Hoang, Tran Thi Kim Chi, Thanh-Danh Nguyen* (2022) Ultrasound-assisted synthesis of gold nanoparticles supported on β-cyclodextrin for catalytic reduction of nitrophenols, Inorganic Chemistry Communications, 145, 109979. (SCIE, Q.2, IF (2021) = 3.428).

- Patents (list): No

- Technological products (describe in details: technical characteristics, place): Nanocomposite products include 5-FU@AuNPs/β-CD, 5-FU@AuNPs/HPCD, and 5‑FU@AuNPs/TMACD with purple color (total weight 1g), storage place: Department of Technology for Pharmaceutical Chemistry - Institute of Chemical Technology.

- Other products (if applicable): Training: 01 PhD student defended the training agency level on November 2022; 01 Master's degree defended September 2022.