Project's information
| Project's title | Elaboration of a well-defined structure of multifunctional hybrid surfaces towards active drug release, antibacterial, and wound healing applications |
| Project’s code | ĐL0000.06/20-22 |
| Research hosting institution | University of Science and Technology of Hanoi |
| Project leader’s name | Assoc. Prof. Nguyen Van Quynh |
| Project duration | 01/01/2020 - 31/07/2023 |
| Project’s budget | 1,000 million VND |
| Classify | Grade B |
| Goal and objectives of the project | - General objectives:
+ Elaborating nanostructured an inorganic-organic hybrid material system based on conducting polymers and metal nanoparticles, towards active drug release, antibacterial, and wound healing applications.
+ Promoting scientific research cooperation between lecturers at University of Science and Technology of Hanoi (USTH) and researchers at research institutes inside Vietnam Academy of Science and Technology (VAST) campus is one of the major objectives of this project. This established cooperation contributes to the development of advanced research domains related to the synthesis and application of regular structures of hybrid materials at USTH.
- Specific scientific objectives:
+ Electrochemical synthesis of metal nanoparticles (AgNPs; AuNPs) embedded in conducting polymer (PPy; PANi; PEDOT). The electrical-optical-biological properties of the as-prepared hybrid materials are fully characterized.
+ Attempting the feasibility of as-fabricated hybrid materials as smart plasmonic surfaces to control drug release and antibacterial. |
| Main results | - Scientific achievements:
+ Successfully fabricated regular structure of hybrid PEDOT/AgNPs, AgNPs size is approximately of 55 nm.
+ Successfully generated inverse opal structure of PEDOT/AgNPs that exhibits a high active volume applied for drug loading up to 31.76%.
+ Investigating the drug release rate at different external voltage applied. The obtained results prove the drug release rate at -0.6 V applied is higher than that of 0 V applied.
+ The as-prepared regular structure of hybrid material has a high potential for generating heat to kill E.Coli under a laser 532 nm irradiation.
- Applied results:
+ Fabricated 04 electrodes (2 cm x2 cm), modified by inversed opal structure of PEDOT/AgNPs toward active drug release, antibacterial, and wound healing applications.
- Publications:
+ 02 SCIE Q1 (IF >4);
+ 01 VAST 1
+ 01 National scientific journal.
- Training: 02 Master in Material Science at USTH. |
| Novelty and actuality and scientific meaningfulness of the results | - Proposed a modified technique to fabricate nanostructures by the nanosphere lithography technique without using any surfactants.
- Successfully fabricated inversed opal hybrid material that has potential application for drug release, sensing, and antibacterial.
- Successfully trained 2 masters in material science and surface engineering. |
| Products of the project | - Scientific papers in referred journals (list):
1. D-H-N. Nguyen, Q.-H. Le, T.-L. Nguyen, V.-T. Dinh, H.-N. Nguyen, H.-N. Pham, T.-A. Nguyen, L.-L. Nguyen, T-M-T Dinh, V.-Q. Nguyen, Electrosynthesized nanostructured molecularly imprinted polymer for detecting diclofenac molecule, Journal of Electroanalytical Chemistry, 2022, 921, 116709.
2. Q.-H. Le, T.-U. Tran, V.-T. Dinh, H.-N. Nguyen, H.-N. Pham, X.-T. Nguyen, L.-L. Nguyen, T.-M.-T. Dinh, V.-Q. Nguyen, Fabrication of an inverse opal structure of a hybrid metal-conducting polymer for plasmon-induced hyperthermia applications, RSC Advances, 2023, 13, 6239-6245.
3. N.M. Thu, D. V Tuan, D.T.T. Ngan, P.H. Nam, N. V Quynh, Silver nanoparticles decorated a hybrid of PANI/MoS2 and PANI/WO3 as potential catalysts for direct photoelectrochemical oxidation of glucose, Vietnam Journal of Chemistry, 2022, 60, 597-605.
4. Q.T. Dinh, V.T Dinh, H.N. Nguyen, T.A. Nguyen, X.T. Nguyen, L.L. Nguyen, T.M.T. Dinh, H.N. Pham, V.Q. Nguyen, Synthesis of magneto-plasmonic hybrid material for cancer hyperthermia, Journal of Military Science and Technology, 2022, 128-137.
- Patents (list): NA
- Technological products (describe in detail: technical characteristics, place):
o 04 electrodes (2 cm x2 cm), modified by inversed opal structure of PEDOT/AgNPs toward active drug release, antibacterial, and wound healing applications.
- Other products (if applicable): trained 2 masters in material science. |
| Recommendations | - The project has fully completed all research contents according to the approved research proposal. The project committed to publish 02 SCIEs (Q2) and 01 VAST2 and trained 01 master. However, at the end of the project, 02 SCIEs (Q1, IF > 4) 01 VAST 1, and 01 national scientific journal (exceeded by 01 as stated in the initial plan) were published; trained 02 masters (Exceeds 01 compared to initial plan). The PI and researchers in the project respectfully request Vietnam Academy of Science and Technology (VAST), Department of Planning and Finance belonging to VAST, University of Science and Technology of Hanoi (USTH) allow the project to be liquidated. |
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