Project's information

Project's title Identification of phytochemicals in the treatment of sarcopenia from Vietnamese medicinal plants
Project’s code QTKR01.01/21-22
Research hosting institution Institute of Marine Biochemistry (IMBC)
Coordinating unit, co-chair College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University; Korea
Project leader’s name PhD. Bui Huu Tai and Prof. PhD. Seung Hyun Kim
Project duration 01/06/2021 - 30/06/2023
Project’s budget 200 million VND
Classify Excellent
Goal and objectives of the project

- Isolation and identification of anti-sarcopenia constitutents from Schisandra species growing in Vietnam
- Education and strengthen the research ability of participated members
- Strengthen the scientific collaboration between Institute of Marine Biochemistry, VAST, Vietnam and College of Pharmacy, Yonsei University, Korea

Main results

- Preparation of methanol extract and screening anti-sarcopenia activity of 4 Schisandra species including S. chinensis, S. sphenanthra, S. perulata, and S. cauliflora. Based on screening results, the fruits of S. cauliflora was selected for further investigation. 
- Isolation and determination of 8 compounds, including 7 dibenzocyclooctadiene lignan and 1 sesquiterpene from the fruits of Schisandra cauliflora. Two compounds were previously undescribed. One among isolated compounds, alismoxide, displayed anti-sarcopenia activity by enhencement of the proliferation of  muscle skeletal cells and increasing the formation of myotubes.
- Strengthen research ability of participated members on the isolation, structural elucidation and evaluation of anti-sarcopenia property.
- The results were published on a paper belonging SCIE indexed journal and contributed on the graduation of 3 bachelor of sciences.
- Strengthen scientific collaboration between Vietnam and Korea, VAST and NRF organizations, Insitute of Marine Biochemistry-VAST and College of Pharmacy-Yonsei University.

Novelty and actuality and scientific meaningfulness of the results

- This is the first study on chemical constitutents of the fruits of Schisandra cauliflora, an endemic plant of Vietnam and newly Schisandra species.
- Isolation and determination of two previously undescribed compounds.
- This is the first study in Vietnam targeting on the evaluation of anti-sarcopenia activity.
- This is the first scientific collaboration project between Institute of Marine Biochemistry and College of Pharmacy.

Products of the project

- Publications: 01 SCIE indexed journal
1. Bui Thi Thu Trang, Nguyen Huy Hoang, Pham Hai Yen, Do Thi Trang, Nguyen Thi Cuc, Duong Thi Hai Yen, Jinyoung Kim, Junjung Choi, Seung Hyun Kim, Bui Huu Tai, Nguyen Xuan Nhiem, Phan Van Kiem, Discovery of 2 new dibenzocyclooctadiene lignans cauliflorins A and B from Schisandra cauliflora, Natural Product Communications, 2023, 18(5), 1934578X231176406
- Patents: none
- Products: A SCIE paper and report of completed joint project are deposited at the Institute of Marine Biochemistry 


- Futher study on chemical constitutents of S. caulifora and other popular Schisandra species in Vietnam should be done to identify anti-sacopenia agents
- Keeping a strengthened scientific collaboration between Institute of Marine Biochemistry-VAST and College of Pharmacy-Yonsei University.

Images of project
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