Project's information

Project's title Development of electrochemical sensors based on hybrid nanostructures for detection of medical residues in water sources
Project’s code VAST 07.05/21-22
Research hosting institution University of Science and Technology of Hanoi
Project leader’s name Dr. Vu Thi Thu
Project duration 01/01/2021 - 30/06/2023
Project’s budget 600 million VND
Classify Grade A
Goal and objectives of the project
To develop electrochemical sensors based on hybrid nanostructures for tracing medical resdues on water sources (pain killers, antibiotics..)
Main results
- Theoretical results: Design and fabricate several thin films adaptable for sensing platforms to analyse important compounds often found in pharmaceutical products such as paracetamol, metroxate, gliadin. The techniques to deposit materials onto electrode surfaces are mainly based on electrochemical approach.
- Applied results: The as-prepared sensors (size 1*2 cm2) are suitble for analysis of content of pharmaceutical compounds in human fluids; or components of medicines. Further investigations are needed to employ these sensors in analysis of the trace of pharmaceutical products in water sources with much lower content.
Novelty and actuality and scientific meaningfulness of the results

We have developed new protocols to deposit thin films suitable for electrochemical sensors such as: AuNPs/rGO-PEDOT:PSS, rGO-CNT, rGO/MIP, Cu-BTC. The protocols to deposite carbonnanomaterials, metal nanoparticles, MIP films are inherited from our previous works. This is the first time we try to utilize electrochemical approach to deposit MOF crystals onto electrode surface. The use of electrochemical approach allows to much improve the homogeneity and electron transfer behavior of the films, thus enhance recorded electrochemical signals. In near future, we will further develop other thin films with well-designed structures that are promising for highly sensitive and selective sensing platforms. We have also successfully utilized the as-developed thin films in electrochemical analysis of paracetamol, metroxate, and gliadin. 

Products of the project

- Scientific papers in referred journals (list):
[1] Angelica Corpuz, Tabkrich Khumsap, Suwussa Bamrungsap, Vu Thi Thu, Loc Thai Nguyen, Epitope imprinted polydopamine and reduced graphene oxide based sensing interface for label-free detection of gliadin, Journal of Food Composition and Analysis, 117, 2023, 105090.
[2] Vu Cam Nhung, Nguyen Ngoc Tien, Dau Thi Ngoc Nga, Pham Do Chung, Nguyen Thi Thanh Ngan, Vu Cam Tu, Vu Thi Thu, Facile preparation of uniform and stable AuNPs/rGO-PEDOT:PSS hybrid film for electrochemical detection of pharmaceutical residue in water, Journal of Nanoparticles Research, 2021, 24:34. ISSN (electronic) 1572-896X. ISSN (Print) 1388-0764.
[3] Thi Thanh Ngan Nguyen, Thanh Giang Bui, Hoang Long Nguyen, Duc Thanh Nguyen, Danh Thanh Nguyen, Tuan Hong Nguyen, Van Hiep Nguyen, Thi Thu Vu, Pyrolytic carbon electrodes and their potential applications in electrochemical sensors, Communications in Physics, 2022, 32(4).  ISSN 0868-3166. 
DOI: https://doi.org/10.15625/0868-3166/16829.
[4] Nguyen Tien Dat, Nguyen Ngoc Tien, Nguyen Thi Thanh Ngan, Vu Thi Thu, Sensing interface based on electrodeposited Cu-BTC microporous film for electrochemical detection of pain killler paracetamol, Analyst, 2023, 148, 1777.
- Technological products:
Electrochemical sensors for tracing pharmaceutical residues in water sources. Technical descriptions: size less than 3 inch2, flexible configuration, able to detect common pain killers or antibiotics with detection limit as low as 1 µM. Storage space: University of Science and Technology of Hanoi.
- Training results: 01 Master, 05 Bachelor students
[1] Nguyễn Đình Hiếu, Electrochemical sensors for detection of narrow therapeutic index drugs, Thạc sĩ, Đại học Khoa học công nghệ Hà Nội, 4/2022-10/2022.
[2] Nguyễn Danh Thành, Fabrication and characterization of graphene oxide and reudced graphene oxide, Bachelor, University of Science and Technology of Hanoi, 4/2021/7/2021
[3] Nguyễn Hoàng Long, Micro 2D carbon electrode prepared by interference lithography and pyrolysis technique, Bachelor, University of Science and Technology of Hanoi, 4/2021-7/2021
 [4] Vu Minh Thu Hybrid nanostructures based on functionalized graphene oxide and metal nanoparticles, Bachelor, University of Science and Technology of Hanoi, 4/2022-7/2022
[5] Bui Duy Hai, Synthesis and characterization of hybrid nanostructures for sensing applications, Bachelor, University of Science and Technology of Hanoi, 4/2022-10/2022
[6] Nguyễn Tiến Đạt, Electrodeposited Cu-BTC films for paracetamol detection, Bachelor, Hanoi University of Science and Technology, 2022

Images of project
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