|Project's title||Tổng hợp polymer thay đổi điện tích ứng dụng trong điều chế liposome vận chuyển thuốc nhằm nâng cao hiệu suất giải phóng thuốc trong tế bào|
|Project’s code||GUST.STS. ĐT2020 – SH11|
|Research hosting institution||Graduate University of Science and Technology|
|Project leader’s name||Phan Thi Kieu Trang|
|Project duration||01/09/2020 - 31/12/2022|
|Project’s budget||408 million VND|
|Goal and objectives of the project|| |
The objective of the topic is to create a new generation of drug transportation system to increase the stay of the drug carrier in the circulatory system, avoid the identification of the body immune system and be able to escape from Endosome to go to go. into the cytoplasm of the drug prevention inside the cell.
|Main results|| |
- Theoretical results:
+ Optimize the conditions and components of polymer synthesis with components that change the charge according to the pH of Pasp environment (Det-Cit) -Toc.
+ Preparation of liposome has a shell that changes the charge according to the pH of the environment to transport anti -cancer drugs to improve the release of the drug in the cell.
- Applied results:
+ Application of drug transportation systems with polymer changes in drug transmission systems, helping to increase the effectiveness of treatment
|Novelty and actuality and scientific meaningfulness of the results|| |
The product of the topic is to create liposomes to transport drugs to the target with high efficiency from the intracellular process by attaching polymers to change the charge according to the environment. The result of the topic is the premise for the next studies on the application of liposome beads mounted polymers to change the environmental pH in the transportation of drugs, especially in cancer treatment, helping to increase the time. The accommodation of the grain is carried in the circulatory system, avoiding the identification of the immune system and escaping from endosome to go inside the cell and release the drug.
|Products of the project|| |
- Scientific papers in referred journals (list):
+ “Fabrication of a charge-conversion polymer – liposome for enhancing endosomal escape of drug delivery system for - Mangostin”, accepted, Manuscript ID: processes-1609889
+ “Nghiên cứu ứng dụng chylomicron tàn dư trong hệ vận chuyển thuốc tới gan”, Tạp chí phân tích Hóa, Lý và Sinh học - Tập 28, Số 1/2023
|Research area||Chemical and Pharmaceutical laboratories to test the activity of synthetic and natural compounds |
|Images of project|| |