Applying modern technologies to build the process of isolation and creation of Murrayafoline A - rich funtional foods that have the effect of preventing and supporting the treatment of cancer from Glycosmis stenocarpa of Vietnam.

- Having researched the construction of Murrayafoline A quantitative methods by HPLC method. On that basis, the content of Murrayafoline A determined in the Glycosmis stenocarpa root was 0.38 - 0.40%
- Having researched the construction of  technological process to isolate Murrayafoline A according to conventional chemical methods with 70% efficiency and product purity reaches > 95%
- Having researched the application of advanced and modern techniques such as using ultrasound in combination with enzyme  to hydrolyse raw material, use steam to enrich the product .... in the process of production Murrayafoline A products from Glycosmis stenocarpa . In which, ultrasound techniques combine enzymes for high efficiency when reducing hydrolysis time, completely releasing secondary compounds including Murrayafoline A into a free form. Thereby helping the product recovery efficiency increased to > 90% and product purity reached> 98%
- Murrayafoline A nanoliposome  has been researched with an average size of 101.18 ± 3.26 nm; PDI = 0.139 ± 0.025; The zeta = -24.2 ± 1.04 (MV); Liposome efficiency reaches 55.3%. The product is evaluated on HEPG2 liver cancer cells, showing the ability to absorb active ingredients significantly to about 8.83 ± 0.97 ng/105 cells compared to 2ng/105 cells
- Successfully researched the technological process and model of 10kg pilot -scale pilot equipment system/ batch extract and purify murrayafoline A from Glycosmis stenocarpa  roots. The process and system of equipment operate stably with an average efficiency of> 95% and the purity reaches> 98%. Murrayafoline A products ensure safety criteria as prescribed by the Ministry of Health
- Successfully researched and prepared for oral tablets containing Murrayafoline A Nano Liposome. Products ensure safety criteria as prescribed by the Ministry of Health.

- Patents (list):
+ Patent No. 28816: " Quy trình phân lập và tinh chế hợp chất 1-methoxy-3-methyl-9H-carbazol từ rễ cây cơm rượu trái hẹp (Glycosmis stenocarpa)". Decision No. 9209W/QD-SHTT, June 3, 2021
+ Patent of registration form -1-2021-08288 " Thiết bị tạo hạt liposome dạng nano " has been granted a decision to accept a valid application No. 1201W/QD-SHTT dated January 24, 2022
- Scientific papers in referred journals (list):
+ Quoc Toan Tran, The Dan Pham, Thanh Duong Nguyen, Van Huyen Luu, Huu Nghi Do, Xuan Duy Le, Phi Hung Nguyen, Manh Cuong Nguyen, Van Chinh Luu, Minh Quan Pham, Thi Huyen Vu, Tri Nhut Pham, Dung Thuy Nguyen Pham (2021), “Optimization of Murrayafoline A ethanol extraction process from the roots of Glycosmis stenocarpa, and evaluation of its Tumorigenesis inhibition activity on Hep-G2 cells, Open Chemistry ISSN 2391-5420, 19, 830-842
+ Trần Quốc Toàn, Lưu Văn Chính, Lê Xuân Duy, Nguyễn Nam Anh, Nguyễn Thành Dương (2022), Nghiên cứu chế tạo hệ vi lưu tổng hợp liposome vận chuyển murrayafoline A ứng dụng hỗ trợ điều trị ung thư, Tạp chí phân tích Hóa, Lý và Sinh học, Tập 27, Số 2/2022
- Technological products (describe in details: technical characteristics, place):
+ 500 grams of Murrayafoline A, purity > 95%, kept at the Institute of natural products chemitry - Vietnam Academy of Science and Technology
+ 500 grams Nano murrayafoline A dissolves well in water, prepared in the form of soft capsules (1000 mg/tablet), kept at the Institute of natural products chemitry - Vietnam Academy of Science and Technology
+01 Liposome synthesis equipment system with capacity of 50ml/h 
- Other products (if applicable):
+ Training: 01 master