Phytochemical investigation of two Pandanus species led to the isolation of 13 compounds from Pandanus tectorius and 13 compounds from Pandanus amaryllifolius. Three new compounds were identified, while several other compounds have been found for the first time from the genus Pandanus. Structures of the isolated compounds were elucidated by spectroscopy methods (NMR, MS, ECD). Evaluation of antioxidants and calcium oxalate crystallization inhibitory effects of the isolated compounds revealed that the lignans showed significant DPPH free radical scavenging activity and considerable inhibition of calcium oxalate crystallization. Meanwhile, the alkaloids, benzofuran, and benzopyran derivatives exhibited weak bioactivities.

3 new compounds were isolated from the aerial parts of Pandanus tectorius and six compounds were detected for the first time from Pandanus species.

- Publications:
[1] Tsvetelina Doncheva, Nadezhda Kostova, Radostina Toshkovska, Stefan Philipov, Vu Duc Nam∗, Nguyen Tien Dat, Nguyen Quang Trung, Do Hoang Giang, Dang Viet Hau. Alkaloids from Pandanus amaryllifolius and Pandanus tectorius from Vietnam and their anti-inflammatory properties. Comptes rendus de l’Acad´emie bulgare des Sciences (2022) 75 (6), 812-820.
[2] Do Hoang Giang, Truong Thi Lien, Dang Viet Hau, Vu Duc Nam, Nguyen Thi Thu Thuy, Nguyen Tien Dat. Calcium oxalate crystallizing inhibition of extracts from several Pandanus species in Vietnam. Journal of Medicinal Materials (2022) (accepted).
- Products: Reports of chemical compositions and bioactivities of two Pandanus species.
- Education and training: 1 Master student