Vietnam Academy of Science and Technology

Project's information

Project's title	Screening for natural compounds that inhibit inflammatory cytokines through the AhR pathway on macrophage cells
Project’s code	GUST.STS.ĐT2019-SH01
Research hosting institution	Graduate University of Science and Technology
Project leader’s name	Tran Minh Duc
Project duration	01/06/2019 - 31/08/2022
Project’s budget	462 million VND
Classify	Excellent
Goal and objectives of the project	Screening for natural compounds that inhibit inflammatory cytokines through the AhR pathway on macrophage cells.
Main results	Theoretical results: The study elucidated the anti-inflammatory role of 9-hydroxycanthin-6-one compound and this anti-inflammatory process through the Ahr molecule. Applied results: This study has shown that the compound taken from the medicinal plant as an anti-inflammatory. This is the starting point for more research into safe and effective natural anti-inflammatory agents.
Novelty and actuality and scientific meaningfulness of the results	- Scientific papers in referred journals (list): 01 SCI/SCIE paper (has been accepted for publication under the Letter to Editor form) Paper’s name (Letter to editor): “Anti-inflammatory activity of 9-hydroxycanthin-6-one extracted from hairy-root cultures of Eurycoma longifolia potentially via Aryl Hydrocarbon Receptor induction” Authors: Duc Minh Tran1, Trang Thu Tran2, Ngan Thi Thuy Nguyen2, Hoang Ha Chu2, Taisuke Nakahama3 and Nam Trung Nguyen2 1Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 2Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. 3Department of RNA Biology and Neuroscience, Osaka University, Suita, Osaka, Japan. Journal: Bangladesh Journal of Pharmacology (IF: 1.143)
Images of project