Project's information

Project's title Study on synthesis and assessment of biotoxicity of contrast agents based on Gd2O3 nanomaterials applied in MRI technique.
Project’s code GUST.STS.ĐT2020-KHVL04
Research hosting institution Graduate University of Science and Technology
Project leader’s name Dr. Nguyễn Thị Thùy Khuê
Project duration 01/06/2020 - 30/06/2022
Project’s budget 408 million VND
Classify Fair
Goal and objectives of the project

To fabricate a superstable magnetic fluid system based on extremely small (1.5–10 nm) Gd2O3 materials coated by biocompatible polymers and to apply as contrast agents in magnetic resonance imaging (MRI) with high resolution, high contrast and low toxicity.

Main results

Theoretical results:
+ To survey and choose the optimal conditions to synthesize nanoparticles from Gd2O3 by 02 methods: thermal decomposition method in organic solvents: reaction temperature 320oC, reaction time 5h, solvent mixture oleic acid: oleylamine = 1:1; polyol method: reaction temperature 200oC, reaction time 6h.
+ To study the characteristic properties of nanoparticles from Gd2O3: composition, structure, morphology, magnetic saturation of the material by methods such as X-ray diffraction method, method by vibrating sample magnetometer , scanning electron microscopy method, dynamic light scattering method and saturation magnetometry.
+ To synthesize magnetic liquid from Gd2O3@PMAO by thermal decomposition in organic solvents and Gd2O3@PVP by polyol method. Characterization of magnetic fluids: transmission electron microscopy, infrared spectroscopy, thermogravimetric analysis, dynamic light scattering and zeta potential measurement.
Applied results:
+ To successfully test MRI and CT imaging on mice using Gd2O3@PMAO and Gd2O3@PVP magnetic fluids as magnetic contrast agents.
+ To successfully check cytotoxicity using liquid from Gd2O3@PMAO and Gd2O3@PVP by MTT method.

Novelty and actuality and scientific meaningfulness of the results

- Preparation of nano-sized Gd2O3, Gd2O3@PMAO and Gd2O3@PVP by chemical methods is much simpler than those of previous publications.
- Successfully tested biological applications such as cytotoxicity testing and MRI and CT scans.
- Confirming the great potential of magnetic fluids can be studied a step further for practical applications with living organisms in imaging diagnostics in the not too distant future.

Products of the project

- Scientific papers in referred journals (list):
Water-dispersible Gadolinium Oxide Nanoplates as an Effective Positive Magnetic Resonance Imaging Contrast Agent. ChemistrySelect. Volume 7, Issue 34. DOI: 10.1002/slct.202202062.
Synthesis and characterization of PVP coated gadolinium oxide nanoparticles for imaging applications. Vietnam Journal of Science and Technology.

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