Project's information

Project's title Research on the use of substances/groups of key substances derived from medicinal plants for quality control of medicinal plants
Project’s code VAST.TĐNDTP.05/16-18
Research hosting institution Institute of Marine Biochemistry (IMBC)
Project leader’s name Dr. Tran Hong Hanh
Project duration 01/01/2019 - 31/12/2021
Project’s budget 7,500 million VND
Classify Excellent
Goal and objectives of the project

- Identify substances/groups of key substances from some medicinal plants.
- Using substances/groups of key substances as markers for quality control of medicinal plants.

Main results

- Isolation and structural identification of 75 compounds from six medicinal plants collected in Vietnam.
- Evaluation in vitro cytotoxic effects against three human cancer cell lines of compounds isolated from six medicinal plants.
- Successful establishment of three processes to isolated key compounds from three medicinal plants.  
- Evaluation of the composition of medicinal plants by HPLC with the aid of chemometrics

Novelty and actuality and scientific meaningfulness of the results

Isolation and structural identification of  six new compounds from six medicinal plants collected in Vietnam.

Products of the project

- Scientific papers in referred journals: published 02 SCI-E and 01 national papers
+ Tran Thi Hong Hanh, Le Ngoc Anh, Nguyen Quang Trung, Tran Hong Quang, Do Hoang Anh, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh. Cytotoxic phenolic glycosides from the seeds of Senna tora. Phytochemistry Letters 45 (2021) 190 –194.
+ Tran Thi Hong Hanh, Pham Thi Cham, Do Hoang Anh, Nguyen The Cuong, Nguyen Quang Trung, Tran Hong Quang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh. Dammarane-type triterpenoid saponin from the buds of Panax pseudoginseng with cytotoxic activity. Natural Product Research (accepted)
+ Trần Thị Hồng Hạnh, Phạm Thị Châm, Đỗ Hoàng Anh, Đặng Việt Cường, Nguyễn Xuân Cường, Nguyễn Hoài Nam, Trần Hồng Quang. Alcaloid iridoid glycosid và bis-iridoid glycoside từ rễ cây Tục đoạn. Tạp chí Dược liệu tập 26, số 4/2021, trang 211-216.
- Other products (if applicable): 03 isolation process, systematic data of chemical constituents of six medicinal plants.

Images of project
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