Project's information

Project's title Finalizing the extraction process and testing the production of capsules for diabetes treatment from Momordica charanta, Gymnema sylvestre and Rehmannia glutinosa
Project’s code UDSXTN.04/20-21
Research hosting institution Institute of Marine Biochemistry (IMBC)
Coordinating unit, co-chair Thanh Cong Science and Technology Trading Co., Ltd
Project leader’s name Dr. Pham Hai Yen
Project duration 01/01/2020 - 31/12/2021
Project’s budget 3,050 million VND
Classify Excellent
Goal and objectives of the project

-    Finalizing the extraction process of 3 medicinal herbs M. charantia, G. sylvestre, R. glutinosa
-    Evaluation of the hypoglycemic effect of preparations containing M. charantia, G. sylvestre and R. glutinosa extracts to select the product with the best hypoglycemic effect.
-    200,000 capsules to support diabetes treatment
-    Standard of the capsule.


Main results

Theoretical results: The process of extraction of 3 medicinal herbs M. charantia, G. sylvestre, R. glutinosa  (100 kg of dry materal/batch) have been completed. These processes are stable performance, feasible in large quantities and safe and environmentally friendly; Isolation and structrural elucidation of 6 main chemical constituents (2 constituents/medicinal herb) as comparators for the evaluation of the extracts. Researched Researched and made TD production. The safety and in vivo hypoglycaemic effects of the TD production have been studied.
Applied results: The process of extraction of 3 medicinal herbs of M. charantia, G. sylvestre, R. glutinosa (100 kg of dry materal/batch) has been completed; A trial batch of 100 kg of semi-finished production (TD production); Produced 200,000 capsules Gluco CB-VHL


Novelty and actuality and scientific meaningfulness of the results

- This is the first diabetes product with a combination of three precious herbs: M. charantia, G. sylvestre, R. glutinosa . The GlucoCB-VHL capsule product, which has the effect of supporting diabetes treatment, is well-researched for its extraction process and pharmacological effects. Extraction technology uses ultrasonic extraction equipment to maximize the extraction of active constituents in medicinal herbs and shorten the extraction time. This is modern technology compared to the region and the world. Research on pharmacological effects was carried out by an experienced expert of the Institute of Biotechnology (Assoc. Prof. Dr. Do Thi Thao), so the obtained results have high accuracy.
- Studies on chemical composition have isolated 2 new constituents from G. sylvestre, 1 new constituent from bitter melon species.

Products of the project

-    Scientific papers in referred journals (list):
1. Pham Hai Yen, Duong Thi Hai Yen, Nguyen Thi Viet Thanh, Nguyen Anh Hung, Ngo Anh Bang, Bui Huu Tai, Nguyen Xuan Nhiem, and Phan Van Kiem, Gymsyloside F and Gymsyloside G, Two New Pregnane Glycosides From the Leaves of Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities, Natural Product Communications Volume 16 (7): 1-6, DOI:   10.1177/1934578X211029532.
2. Duong Thi Hai Yen, Pham Hai Yen, Nguyen Quang Hop, Nguyen Anh Hung, Tran Thi Thu Ha, Bui Huu Tai, Nguyen Xuan Nhiem, and Phan Van Kiem, Charantoside L, A New Cucurbitane-Type Glycosides from Momordica charantia L. with α-Glucosidase Inhibitory Activities, Natural Product Communications, DOI:10.1177/1934578X211068924/ID: NPX-21-0653.R1
3. Pham Hai Yen, Dan Thi Thuy Hang, Nguyen Huy Hoang, Ngo Anh Bang, Duong Thi Hai Yen, Nguyen Anh Hung, Nguyen Thi Viet Thanh, Bui Huu Tai, Nguyen Xuan Nhiem, Phan Van Kiem, Lignans from Gymnema sylvestre, VNU Journal of Science: Natural Sciences and Technology (Submited).
-    Patents (list):
1. Pham Hai Yen, Phan Van Kiem, Pham Van Cuong, Nguyen Xuan Nhiem, Duong Thi Hai Yen, Nguyen Thi Cuc, Bui Huu Tai, Hydroperoxypregnan glycosides and the method of isolating these compounds from Gymnema sylvestre, Application No. 1-2021-05954 and has been accepted the application in accordance with Decision No. 19688w/QĐ-SHTT dated 02/12/2021 of National Office of Intellectual Property.

Research area Thanh Cong Science and Technology Trading Co., Ltd.
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