|Study on osteogeneic activity of natural compound isolated from Clinacanthus nutans (Burm.f.) Lindau
|Research hosting institution
|Institute of Biotechnology
|Project leader’s name
|Nguyen Thi Mai Phuong
|01/01/2020 - 31/12/2021
|600 million VND
|Goal and objectives of the project
Isolation and in vitro investigation of osteogeneic activity of a natural compound in Clinacanthus nutans Lindau to clarify the effect of the plant in treatment of osteoporis and the related diseases.
|Novelty and actuality and scientific meaningfulness of the results
The osteogeneic effect of lupeol on osteoblats MC3T3-E1 was reported in this study for the first time. This substance enhanced the activity of ALP by interacting with key amino acids in the active site of the enzyme. It also strongly increased mineralization in the osteoblasts. At the molecular level, it affected the expression of genes involving in osteoblast differentiation and the MAPK signaling pathway related to cell mineralization and differentiation. These are new scientific data, as the basis for further applied research.
|Products of the project
- Scientific papers in referred journals (list):
|Images of project