- Study on the isolation of bioactive compounds with antimicrobial and anticancer activity from propolis of stingless bee collected in Binh Dinh and Khanh Hoa province.
- Produce of extract from stingless bee propolis with anticrobial activity, that can be applied in health products.

Theoretical results: The chemical composition and biological activity of 2 propolis samples of Lisotrigona furva stingless bee collected in Binh Dinh and Khanh Hoa province have been studied.
- 12 compounds have been isolated and structurally determined from propolis in Binh Dinh provine,  among that 2 new compounds lisofurvin (BĐ1) and dihydrobrasixanthone B (BĐ2) were discovered. Propolis contained xanthone, phenolic và triterpene compounds. Compound α-mangostin (BĐ7) showed strong antimicrobial acvity against  Gram (+) strains, Gram (-) strain P. aeruginosa and fungi C. albicans. Compounds 3-isomangostin (BĐ11) and γ-mangostin (BĐ12) also exhibited activity to Gram (+) strains.
Compound BĐ10 displayed cytotoxcity against 4 cancer cell lines with IC50 ranging from  2,1±0,15 to 9,55±0,50  µg/mL. Compounds BĐ5-6 and BĐ11-12 showed significant or moderate activity against HepG-2, LU và MCF-7 cell lines with  IC50 values of 4,23-11,14 µg/mL.
- From propolis in Khanh Hoa provine, 5 cycloartane triterpens were isolated. These compound were weakly active on Gram (+) strains but not active against Gram (-) strains and  fungus C. albicans. The isolated triterpenes also showd weak activity against tested cancer cell lines.
Applied results:  An extraction process of propolis in 2 kg scale with 68.3 % yield has been completed to produce propolis extract with antimicrobial activity against Gram(+) strain.  The quality standard of propolis extract has been established.

- The chemical composition and biological activity of 2 propolis samples of Lisotrigona furva stingless bee collected in Binh Dinh and Khanh Hoa province have been studied for the first time. Two new compounds lisofurvin (BĐ1) and dihydrobrasixanthone B (BĐ2) were isolated
- Several compounds from propolis showed antimicrobial or anticancer activity activity.

- Scientific papers in referred journals (list):
 1. Vu Thi Kim Oanh, Ha Thi Thoa, Nguyen Thi Minh Hang, Diep Thi Lan Phuong, Nguyen Thi Phuong Lien, Milena Popova, Boryana Trusheva, Vassya Bankova, Thanh Nguyen Le (2021) New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis, Fitoterapia, 149, 104821.
2. Le Nguyen Thanh, Ha Thi Thoa, Nguyen Thi Tu Oanh, Tran Huu Giap, Vu Thi Quyen, Nguyen Thi Thu Ha, Diep Thi Lan Phuong, Nguyen Thi Phuong Lien, Nguyen Thi Minh Hang (2021) Cycloartane triterpenoids and biological activities from the propolis of the stingless bee Lisotrigona furva, Vietnam Journal of Chemistry, 59(4), 426-430.
- Other products (if applicable): Extract of propolis (2.76 kg)

Collaborate with pharmaceutical company to study the health products formulation from propolis extract.

- Chemical composition of stingless bee propolis samples depend on stingless bee species, regions as well as collection time. It’s neccesary to study different stingless bee propolis samples to discover biological activities of different propolis samples.
- Collaborate with scientists in the field of entomology and agriculture to study biodiversity and biological characteristics of stingless bee species in Vietnam and establish stingless bee management manuals in order to get good quality propolis.