Project's information

Project's title Study of oxidative-reduction reactions using sulfur to synthesize heterocyclic compounds
Project’s code KHCBHH01/18-20
Research hosting institution Institute of Chemistry
Project leader’s name Assoc.Prof.Dr. Ngo Quoc Anh
Project duration 01/01/2018 - 31/12/2020
Project’s budget 1,500 million VND
Classify Excellent
Goal and objectives of the project

Study of oxidative-reduction new reactions using sulfur to synthesize heterocyclic compounds.

Main results

- Successfully studied the synthesis reaction process of arylbenzoxazole derivatives, synthesized 21 compounds arylbenzoxazole from 2-Aminophenol và Aldehydes

- Successfully studied the synthesis reaction process of 2-benzoylbenzoxazole derivatives, synthesized 35 compounds 2-benzoylbenzoxazole from 2-Aminophenol và acetophenone

- Successfully studied the synthesis reaction process of Thioamides và Bis-Aza-heterocyclic, synthesized 48 compounds thioamides and Bis-Aza- Heterocyclic from Methylhetarenes.

- Successfully studied the synthesis reaction process of 2-Benzoylbenzoxazoles and 2-Quinolylbenzoxazoles, synthesized 43 compounds 2-Benzoylbenzoxazoles and 2-Quinolylbenzoxazoles from o-Nitrophenol with Acetophenones and Methylquinolines

Novelty and actuality and scientific meaningfulness of the results

-    Successfully researched 4 new methods of synthesizing heterocyclic compounds using sulfur.
-    Proposed mechanisms for research methods.

Products of the project

+ Published articles:
8) Le Anh Nguyen, Thai Duy Dang, Quoc Anh Ngo and Thanh Binh Nguyen. Sulfur-Pr omoted Synthesis of Benzoxazoles from 2-Aminophenolsand Aldehydes. Eur. J. Org. Chem. 2020, 3818.
9) Thi Thu Tram Nguyen, Le Anh Nguyen, Quoc Anh Ngo, Marina Koleski and Thanh Binh Nguyen. The catalytic role of elemental sulfur in the DMSO-promoted oxidative coupling of methylhetarenes with amines: synthesis of thioamides and bis-aza-heterocycles. Org. Chem. Front. 2021, 8, 1593.
10) Le Anh Nguyen, Quoc Anh Ngo, Pascal Retailleau, Thanh Binh Nguyen. Break-and-Build Strategy for the Synthesis of 2-Benzoylbenzoxazoles from o-Aminophenols and Acetophenones. Adv. Synth. Catal. 2021, 363, 2098.
11) Le Anh Nguyen, Thi Thu Tram Nguyen, Quoc Anh Ngo, Thanh Binh Nguyen. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines. Org. Biomol. Chem. 2021. DOI:10.1039/D1OB00976A.
12) Nguyễn Lê Anh, Đoàn Hồng Vân, Ngô Quốc Anh. Một phương pháp mới tổng hợp các dẫn chất 2-Benzothiazole từ các 2-Aminothiophenol và Acetophenon. JST: Engineering and Technology for Sustainable Development. Volume 31, Issue 1, March 2021, 033-036.
13)  Nguyễn Lê Anh, Đặng Thái Duy, Nguyễn Thanh Bình, Ngô Quốc Anh. Nghiên cứu phương pháp mới để tổng hợp các 2-arylbenzoxazole từ dẫn xuất của 2-Aminophenol và Benzaldehyde sử dụng lưu huỳnh làm tác nhân oxi hóa. JST: Engineering and Technology for Sustainable Development. Volume 31, Issue 1, March 2021, 037-040.
14) Nguyễn Lê Anh, Trần Thị Yến, Ngô Quốc Anh, Một phương pháp mới tổng hợp các dẫn chất 2-benzoxazole từ các 2-nitrophenol và aldehyde. JST: Engineering and Technology for Sustainable Development (đã chấp nhận đăng).
+ Educate: Successfully trained 01 PhD student who has defended the academy level.

Images of project
1649817839358-17.2.png