-    Study on the chemical composition of the buds of Tetradium ruticarpum in Vietnam.
-    Investigation of the PTP1B and α-glucosidase inhibitory activities of the compounds isolated.

Theoretical results:
-    Scientific name of the plant material and deposited plant materials with voucher specimen.
-    11 chemical structure with pure compound materials isolated from Tetradium ruticarpum.
-    The PTP1B and α-glucosidase inhibitory activities result of 11 isolates.
-    The inhibitory activity result of isolated compounds on human breast cancer cells (MCF7 and MCF/TAMR).
-    In silico study result of some isolated compounds with protein PTP1B and α-glucosidase by molecular docking simulation using AutoDock software.
Applied results:
-    05 gram of two major active compounds from Tetradium ruticarpum.

-    This is the first time that the chemical constituents of Tetradium ruticarpum and their biological activities (PTP1B and α-glucosidase inhibitory effects) have been studied. In addition to in silico study of the isolated compounds with protein PTP1B and α-glucosidase by molecular docking simulation
-    The inhibitory activity of some isolated compounds on human breast cancer cells (MCF7, MCF/TAMR) has also studied.
-    Education result: 01 master and 01 student majored in organic chemistry are educated.

- List of published papers:
1.    Dao-Cuong To, Thanh Q. Bui, Nguyen Thi Ai Nhung, Quoc-Toan Tran, Thi-Thuy Do, Manh-Hung Tran, Phan-Phuoc Hien, Truong-Nhan Ngu, Phan-Tu Quy, The-Hung Nguyen, Huu-Tho Nguyen, Tien-Dung Nguyen and Phi-Hung Nguyen. On the Inhibitability of Natural Products Isolated from Tetradium ruticarpum towards Tyrosine Phosphatase 1B (PTP1B) and
-Glucosidase (3W37): An In Vitro and In Silico Study. Molecules, 2021, 26, 3691‒3709. (Thuộc tạp chí Q1, IF = 3.2).
2.    Nguyễn Phi Hùng, Trần Quốc Toàn, Nguyễn Anh Tuấn, Trịnh Ngọc Thảo Vy, Ngô Thị Ngọc Yến, Tô Đạo Cường và Đặng Ngọc Quang. Hoạt chất ức chế tế bào ung thư vú trong quả cây Thôi chanh trắng (Tetradium ruticarpum). HNUE JOURNAL OF SCIENCE, Natural Sciences 2021, Vol. 66, Issue 1, 65-71. (DOI: 10.18173/2354-1059.2021-0008).
3.    Minh Quan Pham, Thuy Huong Le Thi, Quoc Long Pham, Le Thi Le, Huy Toan Dao, Thanh Le Thi Dang, Dung Thuy Nguyen Pham and Hai Ha Pham Thi. In Silico Assessment and Molecular Docking Studies of Some Phyto-Triterpenoid for Potential Disruption of Mortalin-p53 Interaction. Processes, 2021

According to the obtained result of the study on the chemical composition and biological activities, especially the PTP1B inhibitory activity, of Tetradium ruticarpum, in addition to the isolation procedure of the two major active compounds, the research team wish to suggest for further research to create effective products which might applicable in treating diabetes and possibly obesity.