Project's information

Project's title Study on the chemical constituents and anti-diabetic activity of Camellia sasanqua
Project’s code GUST.STS.ĐT2018-HH01
Research hosting institution Graduate University of Science and Technology
Project leader’s name Nguyen Thi Cuc
Project duration 01/06/2018 - 30/06/2021
Project’s budget 300 million VND
Classify Excellent
Goal and objectives of the project

Evaluating, screening to search anti-diabetic activity compounds from Camellia sasanqua.

Main results

- Isolated and determined the structure of 13 compounds (CS1-CS13) from species  C. sasanqua. Among the isolated compounds are three  new compounds.
•    Three  new compounds: sasastilboside A (CS1), sasastilboside B (CS2) and sasastilboside C (CS3).
•    Ten known compounds: 3,5-dihydroxydihydrostilbene 4′-O-β-D-glucopyranoside (CS4), 5,4′-dihydroxydihydrostilbene 3-O-β-D-glucopyranoside (CS5), 3,5-dimethoxydihydrostilbene 4′-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (CS6), rehmaionoside A (CS7), kaempferol 3-O-β-D-glucopyranoside (CS8), quercitrin (CS9), rutin (CS10), nicotiflorin (CS11), catechin (CS12) and nudiposide (CS13).
- All compounds from C. sasanqua were evaluated for their α-glucosidase và α-amylase inhibitory effects. As the results: compounds CS3, CS8 and CS12 showed α-glucosidase inhibitory activity with the IC50 values of 77.62 ± 1.58, 123.03 ± 2.08 and 72.44 ± 1.34 μM. Compound CS1 was found to inhibit α-amylase activity with IC50 values of 53.70 ± 1.57 μM.

Novelty and actuality and scientific meaningfulness of the results

- Isolated and determined the structure of three new compounds and ten known compounds from species C. sasanqua. Three new compounds: sasastilboside A (CS1), sasastilboside B (CS2) and sasastilboside C (CS3).
- This is the first time all compounds from C. sasanqua were evaluated for their α-glucosidase và α-amylase inhibitory effects. Three compounds CS3, CS8 and CS12 showed α-glucosidase inhibitory activity with the IC50 values of 77.62 ± 1.58, 123.03 ± 2.08 and 72.44 ± 1.34 μM. Compound CS1 was found to inhibit α-amylase activity with IC50 values of 53.70 ± 1.57 μM.

Products of the project

•    Nguyen Thi Cuc, Nguyen The Cuong, Luu The Anh, Duong Thi Hai Yen, Bui Huu Tai, Duong Thu Trang, Pham Hai Yen, Phan Van Kiem, Nguyen Hoai Nam, Chau Van Minh, Nguyen Xuan Nhiem. Dihydrostilbene glycosides from Camellia sasanqua and their α-glucosidase and α-amylase inhibitory activities. Natural Product Research, (2021), 1-7.
•    Nguyen Thi Cuc, Nguyen Xuan Nhiem, Bui Huu Tai, Van Kiem Phan, Vu Kim Thu. Dihydrostilbene glycosides and lignan from Camellia sasanqua. Vietnam Journal of Chemistry, (2020) 58, 661-665.

Images of project
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