- To obtain a collection of mangrove plants of Ca Mau province with medicinal potential.  
- To obtain the bioative compounds from mangrove plants by using antimicrobial and cytotoxic assay-guided isolation method.
- To propose the use of some mangrove plants with promising bioactivity.

Theoretical results:
- The project has investigated and collected 23 samples of mangrove plants with the scientific names, photos and specimens.
- The project has evaluated the biological activity of crude extracts of mangroves. As the results, the extracts of 22 mangrove species exhibited antimicrobial effect and 11 extracts showed cytotoxic activity.
- 82 compounds were isolated from the methanol extract of 07 mangrove samples by using various chromatographic methods.
- The bioactive evaluation of isolated compounds revealed that 51 compounds showed antimicrobial activity and 10 compounds exhibited cytotoxicity.  
Applied results:
- The project has proposed the use of two promising bioactive mangrove plants, the Rhizophora apiculata and Ceriops decandra.

- This is the first studies on the chemical constituent and bioactivity of 7 mangrove plants of Ca Mau province.
- Three new compounds were isolated and structural elucidated.
- 51 antimicrobial compounds and 10 cytotoxic metabolites were found from 07 Vietnamese mangrove samples.

Scientific papers in referred journals:

• Van Thanh, N., Jang, H.-J., Vinh, L. B., Linh, K. T. P., Huong, P. T. T., Cuong, N. X., Nam, N. H., Van Minh, C., Kim, Y. H., Yang, S. Y. “Chemical constituents from Vietnamese mangrove Calophyllum inophyllum and their anti-inflammatory effects”. Bioorg Chem, 88 (2019) 102921.
• Pham Thanh Binh, Ha Van Oanh, Kieu Thi Phuong Linh, Nguyen Van Chien, Nguyen Quoc Trung, Vu Huy Thong, Nguyen Van Thanh, Nguyen Phuong Thao. “Lignan derivatives from the stem barks of Rhizophora apiculata Blume”. Journal of medicinal materials, 26 (2021) pp. 28 - 34.
•  Kieu Thi Phuong Linh, Pham Thanh Binh, Nguyen Van Chien, Nguyen Quoc Trung, Vu Huy Thong, Nguyen Van Thanh, Nguyen Phuong Thao. “Cytotoxic constituents from the stem barks of Ceriops decandra (Griff.) W. Theob”. Vietnam J. Chem., 2021, 59(3), pp. 362 - 368.

Technological products (describe in details: technical characteristics, place):
- Specimens of 23 mangrove plants of Ca Mau province with the scientific names were deposited at Institute of Marine Biochemistry.
- The spectroscopic data of 82 isolated compounds.
- The result data of antimicrobial and cytotoxic activities of the crude extracts and isolated compounds from mangrove plants.

Institute of Marine Biochemistry and Dat Mui National Park.

We would like to propose to further investigate on the bioactive compounds from the promising bioactive mangrove plants, such as Sonneratia ovata Backer, Gymnanthera oblonga (Burm. f.) P. S. Green, Thespesia populnea (L.) Soland. ex Correa and Sesbania grandiflora (L.) Pers. The bioactive compounds from medicinal plants of semi-island regions and near-shore limestone islands should be investigated.