Project's information

Project's title Formation and properties of thin films and composite materials based on polylactide for biomedical applications.
Project’s code QTBY01.02/18-19
Research hosting institution Institute of Chemistry
Coordinating unit, co-chair Belarus Basic Research Fund
Project leader’s name Dr. Hoang Mai Ha
Project duration 01/01/2018 - 30/06/2020
Project’s budget 200 million VND
Classify Excellent
Goal and objectives of the project

- Develop the cooperation relationships in research and training with Belarus partners to improve the research capacity of Vietnamese scientists.
- Fabrication and determination of morphology, structure and properties of polylactide (PLA) composite with silver nanoparticles or natural organic compounds. Synthesis of polylactide-polyethylene glycol copolymers (PLA-PEG) with different molecular weights for biomedical applications.
- Fabrication and characterization of ultrathin films of SNP/PLA nanocomposite.

 

Main results

The SNP/PLA nanocomposites with different concentrations of silver nanoparticles were synthesized by the melt-blending method. Meanwhile, the homogeneous ultrathin films of SNP/PLA nanocomposite with a thickness of 100-700 nm were prepared by spin-coating technique. UV-Vis spectra and AFM images demonstrated that SNPs were well-dispersed in the PLA matrix with slight aggregations. The mechanical properties of the films were guaranteed for processing and biomedical applications. The films exhibited the highest antimicrobial activity against S. aureus, followed by E. Coli, while the lowest activity was observed against B. subtilis.
Besides, PLA-PEG copolymer was also successfully synthesized and used to prepare nanoparticles of bioactive compounds. The obtained product could be applied in pharmaceutical and food products.
On the other hand, the research team has also published an international article in Advances in Natural Sciences: Nanoscience and Nanotechnology (VAST1), and an article in the Journal of Nanoscience and Nanotechnology (SCI-E), and 3 reports at national/international conferences. In the process of implementation, the project has also contributed to training 01 Ph. D student.

 

Novelty and actuality and scientific meaningfulness of the results

Ultrathin films of SNP/PLA nanocomposites with the different concentrations of silver were successfully synthesized. The homogeneous ultrathin films have good antibacterial properties even at low silver nanoparticles concentration, thus opening up the potential for biomedical applications.
The nanoparticles of bioactive compounds was successfully synthesized using PLA-PEG copolymer.

 

Products of the project

- Publications:
•    Mai Ha Hoang, Hop Tran Thi Thanh, Duc Nghia Nguyen, Tuyen Van Nguyen, Ihnat Chyshankou, Aliaksandr Liubimau, Uladzimir Dobysh and Viktorya Kulikouskaya, Antimicrobial ultrathin film based on welldefined silver nanoparticles and polylactidee, Advances in Natural Sciences: Nanoscience and Nanotechnology, 11 2020 (DOI: 10.1088/2043-6254/ab92f9).
•    Ho Thi Oanh, Nhung Hac Thi, Thanh Nhan Nguyen, Tuyet Anh Dang Thi, Tuyen Van Nguyen, Mai Ha Hoang, Co-encapsulation of lycopene and resveratrol in polymeric nanoparticles: Morphology and lycopene stability, Journal of  Nanoscience and Nanotechnology, 21, 1-9, 2021 (DOI:10.1166/jnn.2021.19146).
     - Reports at national/international conferences:
•    Creation of ultrathin Poly(L-Lactic acid) base films with antibacterial properties, Youth in Science 2019: Proceedings of the XVI International Scientific Conference of Young Scientists (Minsk, October 14-17, 2019). P. 516-518.
•    Synthesis and characterization of polylactidee- based composites, The international scientific conference on Chemistry for Sustainable Development, (CSD2018), 2018.
•    Preparation of nano composite based on Polylactide, 9th National Conference of the Vietnam Organic Chemistry Association, 2019.
- Products (description...):
200g SNP/PLA nanocomposites with silver nanoparticles content of 100ppm and  particle size of 2-3 nm.
- Other products:
The project has also contributed to training 01 Ph. D student.