Project's information
| Project's title | Study on chemical compositions, production process of vegetable oils and piceatannol-containing product from the seeds of Passiflora edulis |
| Project’s code | VAST.CTG.03/17-18 |
| Research hosting institution | Institute of Natural Products Chemistry |
| Project leader’s name | To Dao Cuong |
| Job Title, The rank of a Professor, Academic degree | Dr. |
| Project duration | 01/01/2017 - 31/12/2019 |
| Project’s budget | 600 million VND |
| Classify | Excellent |
| Goal and objectives of the project | - Study on chemical compositions of Passiflora edulis seed oils and process of vegetable oils from the seeds of Passiflora edulis. |
| Main results | Theoretical results + The oil content of the seeds was 24,88 % (w/w) and mainly consisted of linoleic acid (-6, 66,94 %), oleic acid (-9, 18,86 %), sterols (2935,35 mg/kg), triglycerides (monomer TAG, 74,11 %), and tocopherols (18,04 mg/kg). + Developed the process of vegetable oils from the seeds of Passiflora edulis with a scale of 5kg dry material/batch and a hight yield 24,88% (g oil/g material). + Passiflora edulis seed oils do not irritation of the skin with dose 0,5ml after 72h. + Five compounds, trans-resveratrol (PE-1), trans-piceatannol (PE-2), sulfuretin (PE-3), (+)-balanophonin (PE-4) and cassigarol E (PE-5) were isolated from the seeds of Passiflora edulis. Among them, sulfuretin (PE-3) was isolated from Passiflora edulis as well as (+)-balanophonin (PE-4), and cassigarol E (PE-5) were isolated from Passiflora genus for the first time. + Four extracts and four compounds (PE-1 - 3, 5) from the seeds of Passiflora edulis were inhibited the soluble epoxide hydrolase enzyme (sEH). Trans-piceatannol (PE-2) and EtOAc fraction strongly inhibited the enzyme sEH. + Study on the acute toxicity showed that the piceatannol-containing product and seed oils does not cause acute toxicity. Applied results + Developed the process of vegetable oils from the seeds of Passiflora edulis with a scale of 5kg dry material/batch. Passiflora edulis seed oils do not cause acute toxicity and irritate the skin. Passiflora edulis seed oils have great prospects in the food and cosmetic industries. - Preparation containing Piceatannol active ingredient from the seeds of Passiflora edulis with a scale of 5kg dry material/batch have been established. Preparation containing Piceatannol active ingredient does not cause acute toxicity. - Preparation containing Piceatannol active ingredient from the seeds of Passiflora edulis is promising as raw materials for the production of products in the form of supplement foods and drugs to support for the treatment of cardiovascular diseases.   |
| Novelty and actuality and scientific meaningfulness of the results | - Sulfuretin (PE-3) was isolated from the seeds of Passiflora edulis for the first time. |
| Products of the project | - Scientific papers in referred journals (list): + Paper in qualified International Scientific Journal: 01 (Q3): To Dao Cuong, Hoang Thi Ngoc Anh, Tran Thu Huong, Pham Ngoc Khanh, Vu Thi Ha, Manh Hung Tran, Young Ho Kim, and Nguyen Manh Cuong. Identification of Soluble Epoxide Hydrolase Inhibitors from the Seeds of Passiflora edulis Cultivated in Vietnam. Natural Product Sciences, 25(4), 348-353, 2019. + Paper in National Scientific Journal: 01 To Dao Cuong, Doan Lan Phuong, Nguyen Van Tuyen Anh, Pham Ngoc Khanh, Tran Thu Huong, Nguyen Manh Cuong. Chemical compositions of Passifolra edulis seeds oil cultivated in Vietnam. Vietnam Journal of Science and Technology, 2019, 57, 551-558. - Patent/Utility solution: 02 + Patent: Process of producing polyphenols from Passiflora edulis seed and polyphenols that have effects on cardiovascular disease obtained from this process (Accepted, no: 56043/QĐ-SHTT). + Utility solution: Process of vegetable oils from the seeds of Passiflora edulis. (Accepted, no: 19433/QĐ-SHTT). - Technological products: Passiflora edulis seed oils and Piceatannol active ingredient products are stored in Department of Bioactive Products, Institute of Natural Products Chemistry. - Other products (if applicable): no |
| Recommendations | - With the results achieved, the project’s members proposed that the Vietnam Academy of Science and Technology and Institute of Natural Products Chemistry continuing support for the development of the project’s results as pharmaceutical products for life. |
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