Project's information
| Project's title | Study on ataluren synthesis for produce of medicine to treat duhenne and becker muscular dystrophy |
| Project’s code | VAST04.01/18-19 |
| Research hosting institution | Institute of Chemistry |
| Project leader’s name | Trần Đức Quân |
| Job Title, The rank of a Professor, Academic degree | Dr. |
| Project duration | 01/01/2018 - 31/12/2019 |
| Project’s budget | 600 million VND |
| Classify | Excellent |
| Goal and objectives of the project | Build a process of synthesis and purification of ataluren (purity ≥ 99%) with high efficiency and stability. |
| Main results | + Theoretical results:
- Ataluren has been synthesized at the laboratory scale from methyl 3-cyanobenzoate and 2-fluorobenzoyl chloride, with total efficiency of > 70% (based on methyl 3-cyanobenzoate).
- Develop a simple procedure without column chromatography to purify ataluren up to 99% purity (HPLC).
+ Applied results:
Estimated cost of the ataluren synthesized in this project is about ~ 500,000 VND / 1g, only equal to 1/20 (pure chemical form) and 1/40 ( drug form) compared to the current price of ataluren being sold on the market. Therefore, the project results can be applied in practice. |
| Novelty and actuality and scientific meaningfulness of the results | - Has built a process of ataluren synthesis with high efficiency, low price, environmentally friendly and in accordance with the technical conditions in Vietnam |
| Products of the project | + Scientific papers in referred journals (list): 01 publication
- Study on synthesis process of intermediate compound, methyl 3-(N-hydroxycarbamimidoyl) benzoate, for produce of ataluren (Translarna) medicine to treat duhenne and becker muscular dystrophy. Journal of Chemistry, 1-3, Volume 57 (6E12), 2019.
+ Patents (list): 01 Patent for utility solution (GPHI)
- Synthesis process of methyl 3-(N-hydroxycarbamimidoyl) benzoate. The decision to accept the valid application No. 106181 / QD-SHTT dated November 26, 2019
+ Technological products (describe in details: technical characteristics, place):
- Synthesis process of 2-flourobenzoyl chloride
- Synthesis process of methyl 3-cyanobenzoate
- Synthesis process of ataluren
- Synthesis process of ataluren
- A set of documents proving product structure: TLC, mp, 1H, 13C-NMR, LC-HRMS, HPLC spectra
- 40g of ataluren |
| Recommendations | From the achieved results, the research team respectfully recommends the Vietnam Academy of Science and Technology allow following studies: |