Project's information

Project's title Isolation process research of momordicoside A from the fruits of Momordica charantia L. and its anti-diabete activities in in vivo model
Research hosting institution Institute of Marine Biochemistry (IMBC)
Project leader’s name Pham Hai Yen
Project duration 01/01/2012 - 01/01/2013
Project’s budget 500.000.000 Vnd
Classify Excellent
Goal and objectives of the project

- Isolation process of momordicoside A from the fruit of Momordica charantia
- Evaluation the in vivo activities in the treatment of diabetes of momordicoside A
Main results

Theoretical results:
a. Collected 300 kg of dried fruits
b. Isolation process of momordicoside A (20 kg of dried fruits/time)
c. Identified the physical characters and structure of momordicoside A
d. Isolated momordicoside A for in vivo assay (50 g)
e. Isolated 18 compounds including 5 new and 13 known compounds from the fruits of Momordica charantia L.
f. Research indicated the highest contents of momordicoside A at the 30th day after flowering
g. Evaluated α-glucosidase inhibitory activity of momordicoside A (IC50 = 0.47 mM).
h. Identificated the acute toxicity of momordicoside A (result: non-toxic)
i. Evaluated the in vivo activities in the treatment of diabetes of momordicoside A
Novelty and actuality and scientific meaningfulness of the results

a. Isolation process of momordicoside A (20 kg of dried fruits/time)
b. Isolated 18 compounds including 5 new and 13 known compounds from the fruits of Momordica charantia L.
c. Identificated the acute toxicity of momordicoside A (result: non-toxic)
d. Evaluated the in vivo activities in the treatment of diabetes of momordicoside A
Products of the project

-Scientific papers in referred journal : 1 SCI-E paper and 2 Vietnam national papers
Images of project
1598340032990-35. phamhaiyen.jpg