Project's information

Project's title Process for the isolation of Coronarin E from Hedychium coronarium and it’s in vivo activities
Research hosting institution Institute of Marine Biochemistry (IMBC)
Project leader’s name Dr. Hoang Le Tuan Anh
Project duration 01/01/2011 - 01/01/2012
Project’s budget 400.000.000 VND
Classify Excellent
Goal and objectives of the project

-    Process for the isolation of Coronarin E from Hedychium coronarium
-    Evaluation the in vivo activities of Coronarin E
Main results

Theoretical results:
a.    Collection of  samples  (100 kg)
b.    Process for the isolation of Coronarin E (10g/time)
c.    Identification the physical parameters and elucidation the structure of Coronarin E
d.    100g Coronarin E for in vivo assay.
e.    Evaluation the cytotoxic of Coronarin E
f.    Identification the acute toxicity of Coronarin E (LD50 7000mg/kgP)
g.    Evaluation the subchronic toxicity of Coronarin E
h.    Evaluation the in vivo activities of Coronarin E
Novelty and actuality and scientific meaningfulness of the results

a.    Process for the isolation of Coronarin E (10g/time).
b.    Identification the physical parameters and elucidation the structure of Coronarin E
c.    Identification the acute toxicity of Coronarin E (LD50 7000mg/kgP)
d.    Evaluation the subchronic toxicity of Coronarin E
e.    Evaluation the in vivo activities of Coronarin E
f.    Isolating of 4 new compounds and 7 known compounds from Hedychium coronarium.
Products of the project

Scientific papers in referred journal: 2 SCI papers and 1 national paper 
Recommendations

-    The project’s results suggest that Hedychium coronarium and Coronarin E can be developed into products that prevent cancers and related.
-    The labdane-diterpenes from Hedychium coronarium have interesting bioactivities so more in vivo research of methanol extracts is needed.