Project's information

Project's title Research on technological process of extraction and purification of the α-mangostin and bioactive substances from the fruit hull of mangosteen (Garcinia mangostana L.) for making suppletive drugs used in cancer treatment
Project leader’s name Dr. Do Thi Tuyen
Project duration 01/01/2010 - 01/01/2011
Project’s budget 300.000.000 VND
Classify Excellent
Goal and objectives of the project

Development of technological process for extraction and purification of the α-mangostin and other bioactive substances from the fruit hull of mangosteen (Garcinia mangostana L.) for making suppletive drugs used in cancer treatment
Main results
  • Technology for purification process of the α-mangostin from the fruit hull of mangosteen on laboratory scale and 100 kg raw material/batch on pilot scale. Product of 20g α-mangostin.
  • Investigation of biological activities of the isolated substances: antibacterial, antifungal, antioxidant and anti-cancer activity on two cancer cell lines: LU- cells lung cancer, colon SW480 cells cancer and fibroblast cells isolated from mouse peritoneal.
  • Analysis and examination of product and study on the stability the of mangostin product: Determination of acute and sub-chronic toxicity. Establishment of standard basis of semi-product mangostin and pure mangostin.
Novelty and actuality and scientific meaningfulness of the results

Development of technological process for extraction and purification of the α-mangostin from the fruit hull of mangosteen with 100 kg raw material/batch on pilot scale. To provide an appropriate technical parameters used in Vietnam climatic conditions.
Recommendations

To continue production of ?-mangostin in large scale and examine the product on different cancer cell lines.