Project's information

Project's title Synthesis of magnetic nanoparticles with attached antibodies to diagnose the disease in humans and animals
Research hosting institution Ho Chi Minh City Institute of Physics
Project leader’s name Ass. Prof. dr. Tran Hoang Hai
Project duration 01/01/2009 - 01/01/2010
Project’s budget 350 000 000 VND
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Goal and objectives of the project

Development of  manufacturing processes of iron oxide nanoparticles and immobilising antibodies to early diagnosis of cancer and infectious diseases
Main results

Theoretical results:

  • Monte Carlo simulation of magnetic nanoparticle system.
  • Developing of the processes of synthesis of nanoscale iron oxide particles and magnetic properties can stability in biomedical applications and coating layers with biologically active and capable of adhesion antibodies.

Applied results: Early diagnosis of acute diarrhea caused by E. Coli bacteria.
Novelty and actuality and scientific meaningfulness of the results

 Introduce a new method can diagnose early the cancer and infectious diseases

 
Products of the project
  • Scientific papers in referred journals (list):

A. Journals with  SCI/SCIE:

  1. Tran Hoang Hai, et al., “Immobilising of anti-HPV18 and E. coli O157:H7 antibodies on magnetic silica-coated Fe3O4 for early diagnosis of cervical cancer and diarrhea”, International Journal of Nanotechnology Vol. 8, 2011, pp. 383-398, ISSN: 1475-7435
  2. Tran Nguyen Lan and Tran Hoang Hai, “Role of poly-dispersity and dipolar interaction in magnetic nanoparticle systems: a Monte Carlo study”, Journal of Non-Crystalline Solids Vol. 357, 2011, pp. 996-999, ISSN: 0022-3093
  3. Tran Nguyen Lan and Tran Hoang Hai, “Monte Carlo simulation of magnetic nanoparticle system”, Computational Materials Science Vol. 49, 2010, pp. S287-S290
  4. Doan Thi Kim Dung, Tran Hoang Hai, et al., “Preparation and characterization of magnetic nanoparticles with chitosan coating”, Journal of Physics: Conference Series Vol. 187, 2009, pp. 012036(1-5), ISSN: 1742-6588
  5. B. Monographs: Tran Nguyen Lan and Tran Hoang Hai, Using the Monte Carlo Method to study the magnetic properties of frozen ferrofluids, book chapter, 2011, pp. 495-512, in: Application of Monte Carlo simulation of Monte Carlo method in science and technology, Ed. S. Mark and S. Mordechai, INTECH Open Access Publisher, Austria

Technological products (describe in details: technical characteristics, place):

  1. Fe3O4 nanoparticles with size: 5 to 10 nm, 15 to 20 nm, 25 to 35 nm and saturation magnetization: 50 to 70 emu/g ( being kept in the laboratory)
  2. Fe3O4 liquids with coating having bioactive: starch, Dextran, Chitosan,,, and saturation magnetization: 25 to 40 emu/g (being kept in the laboratory).
Research region

The laboratory of the hospital.