Vietnam Academy of Science and Technology

Project's information

Project's title	Study on chemical constituents of Sapindus mukorossi Gaertn. fruit and orientation for creating dishwashing liquid
Project’s code	ĐLTE00.02/24-25
Research hosting institution	Institute of Chemistry
Project leader’s name	Dr. Le Thi Vien
Project duration	01/01/2024 - 30/06/2026
Project’s budget	600 million VNĐ
Classify	Grade B
Goal and objectives of the project	- Isolation and structural elucidation of compounds from Sapindus mukorossi Gaertn. - Orientation of Sapindus mukorossi fruit extract for creating dishwashing liquid
Main results	- Eight compounds with three new ones namely mukurozioside A (SM1), mukurozioside B (SM2), mukurozioside C (SM3) and five known ones mukurozidiol 1-O-a-L-rhamnopyranosyl-(1®2)-O-[a-L-rhamnopyranosyl-(1®3)]-b-D glucopyranoside (SM4), mukurozioside IIa (SM5), mukurozioside IIb (SM6), prosapogenin (SM7), sapindoside A (SM8) were isolated and structurally elucidated from the MeOH extract of Sapindus mukorossi fruit. - The antibacterial activity of eight isolated compounds from Sapindus mukorossi fruit was evaluated. The results showed that: SM7 and SM8 inhibit the growth of Bacillus cereus ATCC14579 bacteria with MIC values of 100 and 50 µM, respectively. - A process to create a soapberry dishwashing liquid at laboratory model was built. - Published one international article.
Novelty and actuality and scientific meaningfulness of the results	- Successful isolation and structural elucidation of three new compounds namely mukurozioside A (SM1), mukurozioside B (SM2), mukurozioside C (SM3) as well as evaluation of their antibacterial activity. - The firt isolation of compound mukurozidiol 1-O-a-L-rhamnopyranosyl-(1®2)-O-[a-L-rhamnopyranosyl-(1®3)]-b-D-glucopyranoside (SM4) from natural sources.
Products of the project	- Scientific papers in referred journals: Le Thi Vien, Do Hoang Anh, Pham Thi Mai Huong, Pham Thi Cham, Ninh Thi Ngoc, Nguyen Mai Anh, Nguyen The Cuong, Tran Thi Hong Hanh, Nguyen Xuan Cuong. Sesquiterpene glycosides from Sapindus mukorossi. Phytochemistry Letters, 2025, 65, 128–132 - Other products (store at the Institute of Chemistry): + Report of isolation of compounds from Sapindus mukorossi fruit + Report of structure elucidation of isolated compounds from Sapindus mukorossi fruit + Report of antibacterial effect evaluation of isolated compounds from Sapindus mukorossi fruit + The process to create a soapberry dishwashing liquid at laboratory model + The soapberry dishwashing liquid (10 L)
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