Project's information
| Project's title | Fabrication of metal – organic framework materials for ultra-trace electrochemical determination of glyphosate in the environment |
| Project’s code | VAST07.05/23-24 |
| Research hosting institution | Institute of Chemistry |
| Project leader’s name | Assoc. Prof. Dr. Vu Thi Thu Ha |
| Project duration | 01/01/2023 - 31/12/2024 |
| Project’s budget | 600 million VND |
| Classify | Grade A |
| Goal and objectives of the project | The main objective of the project is fabrication of metal-organic framework (MOF) materials with effective glyphosate adsorption and application to the development of electrochemical sensors for ultra-trace detection of glyphosate in the environment. |
| Main results | Theoretical results:
Fabricated metal-organic framework materials: single metallic (CuBTC) and bimetallic MOFs (Fe-CuBTC, Zr-CuBTC) then used as modifiers for elctrochemical sensor development.
After screening, the results showed that the bimetallic Zr-CuBTC MOF is the most
promising for the determination of glyphosate by electrochemical sensor. Morphological and structural studies indicated that the coordination of Cu2+ with the presence of Zr4+ ions with BTC ligands provided a highly porous framework, which achieved an active surface area up to 1337 m2 g-1. The pore diameter and pore volume obtained as 1.75 nm and 0.687 cm3 g-1, respectively.
Succesfully fabrication of Zr-CuBTC/GCE with high reproducibility (RSD=4,7%), high sensitivity (ten times higher than using CuBTC without Zr4+ in the frame), low LOD = 9×10-13 M) and good stability (95.7%) and the response time is 4.8 s. After 5 days of storage, 85% signal remained. The developed sensor based on Zr-CuBTC exhibited reliable performance and was employed to analyze Red River water samples with high recoveries (94.6-107.1%), consistent with LC-MS/MS measurements. This sensing platform has potential for monitoring herbicides in aqueous samples
Developed sensors using CuBTC combined gold particles had been fabricated to increase the conductivity, electrocatalytic ability and their synergistic effects (CuBTC/AuPs/GCE sensor). They have good charge transfer ability, large electrochemical active area, and good sensitivity towards glyphosate. The obtained sensitivity is 1.1×109 µA.mM.cm-2 , low LOD = 4.4×10-13 M with a good reproducibility of 2.2%, stability is 97.8% with and the response time of 4.8 s. The measured real samples have excellent recovery (100%) and are consistent with the LC-MS/MS reference measurement results.
Applied results:
The fabricated sensors have been successfully tested for analysing real samples from the Red River. The results show that the sensors are suitable for analytical applications in the laboratory as well as in the field. |
| Novelty and actuality and scientific meaningfulness of the results | Some metal-organic framework materials had been fabricated and used to develop modified electrodes and then successfully applied in the analysis of glyphosate contaminations in the laboratory as well as in the field. The results show that the sensors can detect glyphosate at lower cencentrations than some others published so far. |
| Products of the project | Scientific papers in referred journals:
Ultra-Trace Electrochemical Determination of Glyphosate Using Bimetallic Metal–Organic Frameworks (MOFs) with Differential Pulse Voltammetry. Thi Ngoc Anh Nguyen, Manh B. Nguyen, Trong Hoat Dinh, Cam Tu Vu, Thi Hai
Yen Pham, Hong Phong Pham, Ngoc Tien Nguyen, Quang Hai Tran, Thi Kim
Thuong Nguyen & Thi Thu Ha Vu, ANALYTICAL LETTERS, 2024, VOL. 57, NO. 15, 2497–2511, https://doi.org/10.1080/00032719.2023.2297408 (SCIE, Q3, IF 2.267).
Development of an electrochemical sensor based on the combination of copper-based metal-organic framework and gold particles for glyphosate detection in water, Bui Thi Luyen, Dau Thi Ngoc Nga, Pham Thi Hai Yen, Nguyen ThiThanh Ngan, Vu Cam Tu, Pham Hong Phong, Nguyen Thi Kim Thuong, Vu Thi Thu Ha, VIETNAM JOURNAL OF CHEMISTRY, 2024, 1-9, DOI: 10.1002/vjch.202400265 (VAST 1, Scopus, Q3).
Technological products: (describe in details: technical characteristics, place):
05 electrodes modified by Zr-CuBTC (Zr-CuBTC/GCE sensor), LOD towards glyphosate = 9×10-13 M, with good selectivity, durability and stability (95.3%), good recovery (94.6-107.1%). The validated results are highly compatible with LC-MS/MS analysis.
05 electrodes modified by CuBTC combined with gold particles (CuBTC/AuPs/GCE sensor) LOD towards glyphosate = 4.4×10-13 M, stability = 97.8%, recovery = 100%. The validated results are in good agreement with LC-MS/MS
02 scientific publications in SCIE and Scopus journals. |
| Images of project |
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