Research on the synthesis process of targeting liposomes with chemical-physical-biological stability for application in drug delivery for cancer treatment.

-    Technological results: 
Successfully developed the synthesis process for targeting liposomes.
Successfully developed the process of loading drugs into targeted liposomes.
-    Applied results: Targeted liposomes are safe in in-vitro tests, and the drug-loaded targeted liposomes enhance the effectiveness of cancer drugs

Targeted liposomes are capable of encapsulating quercetin and other cancer drugs, leading to a reduction in dependence on high-cost imported drugs. This development has the potential to lower the cost of domestic drug production, thereby reducing treatment costs for patients and enhancing the country’s self-sufficiency in drug supply, especially for cancer treatment.

- Patents (list):
Quy trình tổng hợp vật liệu gelatin-polyetylen glycol-axit folic (Gel-PEG-FA) dùng trong hệ tổng hợp nano hướng đích, vật liệu Gel-PEG-FA thu được từ quy trình này và quy trình tổng hợp liposom được biến tính bề mặt bằng vật liệu Gel-PEG-FA này 
- Scientific papers in referred journals (list):
1. Nguyen‐Huu, A.M., Le, N.T.T., Yen, P.N.D., Ching, Y.C. and Nguyen, D.H., 2022. Self‐assembly of methoxy poly (ethylene glycol)‐cholesterol micelles for controlled quercetin delivery with toxicity test in Danio rerio model. Journal of Applied Polymer Science, 139(37), p.e52855.
2. Nguyen-Huu, A.M., Le, N.T.T., Vo Do, M.H., Dong Yen, P.N., Nguyen-Dinh, T.D., Nguyen, N.H. and Nguyen, D.H., 2024. Development and Characterization of Quercetin-Loaded Polymeric Liposomes with Gelatin–Poly (ethylene glycol)–Folic Acid Coating to Increase Their Long-Circulating and Anticancer Activity. ACS Applied Bio Materials.
- Technological products (describe in details: technical characteristics, place):
1. 100 mg of targeted liposomal product
The sample must be stored in 2 - 8 °C
100 mg of drug-loaded targeted liposomal product
The sample must be stored in 2 - 8 °C
- Other products (if applicable): 2 processes (Synthesis process of targeting liposomes and synthesis process of loading drugs into targeted liposomes) and 2 Master’s theses.