Project's information
| Project's title | Study on the chemical constituents, caspase activity and preparation of product to assist treatment of cancer of Alpinia vietnamica H.Đ.Trần, Luu & Skornick.sp.nova |
| Project’s code | VAST04.04/22-23 |
| Research hosting institution | Institute of Chemistry |
| Project leader’s name | Dr. Nguyen Thanh Tra |
| Project duration | 01/01/2022 - 31/12/2024 |
| Project’s budget | 600 million VND |
| Classify | Excellent |
| Goal and objectives of the project | - Isolation and structural elucidation of chemical components from Alpinia Vietnamica.
- To prepare orientedly product having capacity of anti tumor of Alpinia Vietnamica. |
| Main results | * Theoretical results:
- Isolated and identified chemical structure of 7 compounds including 2 flavone, 3 flavanone and 3 chalcone as well as hydrodistillated the rhizome and leaf essential oils of Alpinia Vietnamica.
-Evaluation of cytotoxicity, anti-imflammatory, antioxidative, inhibit α-glucosidase activity of extracts and compounds.
*Applied results
-Preparation of the product have antitumor potential at the scale of 1 kg dry material/batch.
-Preparation of 58.4 g product from EtOAC extract having potent anti tumor in rats.
-Evaluation of the acute toxicity of the product (LD50> 5000mg/kg rat body weight) |
| Novelty and actuality and scientific meaningfulness of the results | - Phytochemical and bioactivity research of Alpinia Vietnamica were investigated for the first time, including 7 compounds, the rhizome and leaf essential oils, many of them showed significant bioactivity.
- This is the first report on preparation of the product inhibited 25,72% tumor volume at 500 mg/kg rat body weight. |
| Products of the project | -Technological products (deposited in the Institute of Chemistry) |
| Images of project |  |
