Project's information
| Project's title | Transition metal (Ag/ZnO, Au/ZnO) based biomaterials for phase-specific tissue regeneration |
| Project’s code | QTRU01.02/21-22 |
| Research hosting institution | Institute of Materials Science |
| Coordinating unit, co-chair | Russian Foundation for Basic Research, Russian Federation |
| Project leader’s name | Dr. Cong Hong Hanh and Acc. Prof., Dr. Abdullin Timur I. |
| Project duration | 01/05/2021 - 31/05/2024 |
| Project’s budget | 200 million VND |
| Classify | Fair |
| Goal and objectives of the project | Synthesis and application of transition metal nanoparticles (Ag/ZnO, Au/ZnO) to increase the tissue regeneration efficiency of biomaterials at different stages. |
| Main results | - About science: The project has produced solution of silver nanoparticles and gold nanoparticles by green chemical synthesis method, using Syzygium nervosum leaf extract as a reducing agent. The synthesized silver nanoparticles absorb waves with wavelengths in the range of 400 - 450 nm, with a maximum peak at 435 nm, characteristic of plasmon absorption of silver nanoparticles. Silver nanoparticles are spherical in shape, have a pentagonal crystal structure, and the particle size is not uniform, averaging in the range of 5-30 nm. The synthesized gold nanoparticles absorb waves with wavelengths in the range of 520 - 560 nm and a maximum peak at 540 nm, with an average size of 30 - 40 nm. The optimal conditions for synthesizing gold nanoparticles using Syzygium nervosum leaf extract are at a temperature of 30°C, with the volume ratio of HAuCl4: S.nervosum extract at 1:1, using stabilizer PVP. Au/ZnO and Ag/ZnO nanocomposites were synthesized. Small-sized Au and Ag nanoparticles are scattered among large-sized ZnO particles (200 – 300 nm). The synthesized nanoparticles all exhibit antibacterial and antifungal activity.
The biomaterial produced by Russian researchers has been shown to effectively support cell growth, cell proliferation, increase cell differentiation, and have higher adhesion than cultured polystyrene surfaces.
- Application: The materials of the project show good effectiveness in in vitro conditions, can be further developed in in vivo conditions, and applied to develop wound healing products.
- Training: One bachelor of pharmacists was trained and defended at the Faculty of Pharmacy, Hanoi University of Business and Technology.
- Cooperative development: With obtained the results the two research groups can continue to develop further research to perfect products with antibacterial activity for use in wound healing treatment. |
| Novelty and actuality and scientific meaningfulness of the results | Silver nanoparticles were produced from the project taking advantage of the available and abundant raw materials in Vietnam (Syzygium nervosum leaf extract). Silver nanoparticles were synthesized by an environmentally friendly chemical method, showed positive antibacterial activities against the antibiotic-resistant bacterial strain S.aureus isolated from mastitis cows in Vietnam, which provides an alternative treatment to antibiotics for cases where pathogens carry antibiotic resistance genes. |
| Products of the project | - Publications: Dayob K., Zengin A., Garifullin R., Guler M.O., Abdullin T.I., Yergershov A., Salakhieva D.V., Cong H.H., Zoughaib M. Metal-Chelating self-assembling peptide nanofiber scaffolds for modulation of neuronal cell behavior/ Micromachines 2023, 14, 883. https://doi.org/10.3390/mi14040883 |
| Recommendations | With the positive obtained results, we can see the prospects of developing nanomaterials combined with biological materials in treating infections and healing wounds. Both research groups need to continue to develop larger-scale studies, as well as implement more in-depth goals to perfect the product so it can be applied in practical treatment. |
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